The complete 5′ and 3′ non-coding regions of two attenuated South American foot-and-mouth disease virus (FMDV) vaccine strains, OC-O/E and CR-O/E, and their corresponding virulent parental strains, O Campos and C Resende, have been cloned from polymerase chain reaction-amplified primary cDNA. Differences observed in the derived nucleotide sequences between attenuated and virulent viruses seem not to affect regulatory signal structures, supporting the theory that genetic variations, primarily in the 3′ halves of the viral genomes, contribute to the attenuation phenotype of the vaccine strains. In addition, this is the first report on the complete sequence of the 5′ untranslated region of a C-type aphthovirus. Approximately 10% of the nucleotides differ from the corresponding known sequences of serotypes A or O.


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