1887

Abstract

Release of α-amino[C]isobutyric acid from ferret Mpf cells was promoted by staphylococcal α toxin, diphtheria toxin and streptolysin S. This release was enhanced to a significant extent if the cells had been previously infected with influenza virus strain A/Puerto Rico/8/34 (PR8, H1N1), although infection with virus alone did not increase the release of radiolabel as compared with that from untreated cells; inactivated virus had a similar enhancing action. The mechanism of enhancement is unclear but it occurs between 0.5 and 2 h post-inoculation and viral membrane/endosome membrane fusion is essential. Endotoxin had no effect on membrane permeability, either alone or with PR8. The relevance of these observations to the previously observed enhancement of toxin lethality by influenza virus is discussed.

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1991-01-01
2021-10-18
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