1887

Abstract

Six major epitopes have been recognized within the transmembrane gp41 molecule of human immunodeficiency virus type 1 (HIV-1). The immunodominant epitope is also recognized by antibodies in sera from laboratory personnel and is similar to a linear sequence of amino acids in the genome protein of two rhinovirus serotypes. The hypothesis is presented that immunodominance is produced by multiple priming of the host, following repeated infections with viruses unrelated to HIV-1, which share similar epitopes.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-71-9-1975
1990-09-01
2021-10-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/71/9/JV0710091975.html?itemId=/content/journal/jgv/10.1099/0022-1317-71-9-1975&mimeType=html&fmt=ahah

References

  1. Chiodi F., Mathiesen T., Albert J., Parks E., Norrby E., Wahren B. 1989; IgG subclass responses to a transmembrane protein (gp41) peptide in HIV infection. Journal of Immunology 142:3809–3814
    [Google Scholar]
  2. Dalgleish A. G., Chanh T. C., Kennedy R. C., Kanda P., Clapham P., Weiss R. A. 1988; Neutralization of diverse HIV-1 strains by monoclonal antibodies raised against a gp41 synthetic peptide. Virology 165:209–215
    [Google Scholar]
  3. Desrosiers R. C., Wyand M. S., Kodoma T., Ringler D. J., Arthur L. O., Sehgal P. K., Letvin N. L., King N. W., Daniel M. D. 1989; Vaccine protection against simian immunodeficiency virus infection. Proceedings of the Naitonal Academy of Sciences, U.S.A 86:6353–6357
    [Google Scholar]
  4. Evans D. J., McKeating J., Meredith J. M., Burke K. L., Katrak K., John A., Ferguson M., Minor P. D., Weiss R. A., Almond J. W. 1989; An engineered poliovirus chimaera elicits broadly reactive HIV-1 neutralizing antibodies. Nature; London: 339:385–388
    [Google Scholar]
  5. Gelderblom H. R., Ozel M., Pauli G. 1989; Morphogenesis and morphology of HIV structure-function relations. Archives of Virology 106:1–13
    [Google Scholar]
  6. Gnann J. W., Nelson J. A., Oldstone M. B. A. 1987; Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. Journal of Virology 61:2639–2641
    [Google Scholar]
  7. Ho D. H., Sarngadharan M. G., Hirsch M. S., Schooley R. T., Rota T. R., Kennedy R. C., Chanh T. C., Sato V. L. 1987; Human immunodeficiency virus-neutralizing antibodies recognize several conserved domains on the envelope glycoproteins. Journal of Virology 61:2024–2028
    [Google Scholar]
  8. Kennedy R. C., Henkel R. D., Paulett D., Allan J. S., Lee T. H., Essex M., Dreesman G. R. 1986; Antiserum to a synthetic peptide recognizes the HTLV-III envelope glycoprotein. Science 231:1556–1559
    [Google Scholar]
  9. Kieny M. P., Rautmann G., Schmitt D., Dott K., Wain-Hobson S., Alizon M., Girard M., Chamarer S., Laurent A., Montagnier L., Lecocq J. P. 1986; AIDS virus env protein expressed from a recombinant vaccinia virus. Bio/Technology 4:790–795
    [Google Scholar]
  10. Lipman D. J., Pearson W. R. 1985; Rapid and sensitive protein similarity searches. Science 227:1435–1441
    [Google Scholar]
  11. Mathiesen T., Sonnerborg A., Von Sydow M., Gaines H., Wahren B. 1988; IgG subclass reactivity against human immunodeficiency virus (HIV) and cytomegalovirus in cerebrospinal fluid and serum from HIV-infected patients. Journal of Medical Virology 25:17–26
    [Google Scholar]
  12. Mathiesen T., Chiodi F., Broliden P. -A., Albert J., Houghten R. A., Utter G., Wahren B., Norrby E. 1989a; Analysis of a subclass-restricted HIV-1 gp41 epitope by omission peptides. Immunology 67:1–7
    [Google Scholar]
  13. Mathiesen T., Broliden P. -A., Rosen J., Wahren B. 1989b; Mapping of IgG subclass and T-cell epitopes on HIV proteins by synthetic peptides. Immunology 67:453–459
    [Google Scholar]
  14. Matthews T. J., Langlois A. J., Robey W. G., Chang N. T., Gallo R. C., Fischinger P. J., Bolognesi D. P. 1986; Restricted neutralization of divergent human T-lymphocyte virus type III isolates by antibodies to the major envelope glycoprotein. Proceedings of the National Academy of Sciences, U.S.A 83:9707–9713
    [Google Scholar]
  15. Murphey-Corb M., Martin L. N., Davison-Fairburn B., Montelaro R. C., Miller M., West M., Ohkawa S., Baskin G. B., Zhang J. -Y., Putney S. D., Allison A. C., Eppstein D. A. 1989; A formalin-inactivated whole SIV vaccine confers protection in macaques. Science 246:1293–1297
    [Google Scholar]
  16. Pinter A., Honnen W. J., Tilley S. A., Bona C., Zaghouani H., Gorny M. K., Zolla-Pazner S. 1989; Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1. Journal of Virology 63:2674–2679
    [Google Scholar]
  17. Sanchez-Pescador R., Power M. D., Barr P. J., Steimer K. S., Stempien M. M., Brown-Shimer S. L., Gee W. W., Renard A., Randolph A., Levy J. A., Dina D., Luciw P. A. 1985; Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science 227:484–492
    [Google Scholar]
  18. Schneider J., Kaaden O., Copeland T. D., Oroszlan S., Hunsmann G. 1986; Shedding and interspecies type sero- reactivity of the envelope glycopolypeptide gpl20 of the human immunodeficiency virus. Journal of General Virology 67:2533–2538
    [Google Scholar]
  19. Staden R. 1988; Methods to define and locate patterns of motifs in sequences. Cabios 4:53–60
    [Google Scholar]
  20. Steimer K. S., Van Nest G. A., Haigwood N. L., Tillson E. M., George-Nascimento C., Barr P. J., Dina D. 1988; Recombinant env and gag polypeptides in characterizing HIV-1-neutralizing antibodies. In Vaccines ’88 pp. 347–355 Ginsberg H., Brown F., Lemer R. A., Chanock R. M. Edited by New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  21. Sundqvist V. -A., Linde A., Kurtu R., Werner A., Helm E. B., Popovic M., Gallo R. C., Wahren B. 1986; Restricted IgG subclass responses to HTLV III/LAV and to cytomegalovirus in patients with AIDS and lymphadenopathy syndrome. Journal of Infectious Diseases 153:970–973
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-71-9-1975
Loading
/content/journal/jgv/10.1099/0022-1317-71-9-1975
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error