RT Journal Article SR Electronic(1) A1 Hecht, Eva-Maria A1 Chesters, P. M. A1 McCance, D. J.YR 1990 T1 Human Papillomavirus Type 16 DNA Expresses a Replication Modulation Factor in cos-1 Cells JF Journal of General Virology, VO 71 IS 8 SP 1823 OP 1828 DO https://doi.org/10.1099/0022-1317-71-8-1823 PB Microbiology Society, SN 1465-2099, AB Plasmid DNA including the simian virus 40 (SV40) origin of replication undergoes uncontrolled, runaway replication in cos-1 cells owing to the intracellular production of SV40 large T antigen. Covalent linkage of such plasmids with human papillomavirus type 16 (HPV-16) DNA was found to prevent runaway replication. Replication control was found to be dependent on the presence of HPV-16 DNA sequences including the El open reading frame and part of the non-coding region., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-8-1823