@article{mbs:/content/journal/jgv/10.1099/0022-1317-71-8-1823, author = "Hecht, Eva-Maria and Chesters, P. M. and McCance, D. J.", title = "Human Papillomavirus Type 16 DNA Expresses a Replication Modulation Factor in cos-1 Cells", journal= "Journal of General Virology", year = "1990", volume = "71", number = "8", pages = "1823-1828", doi = "https://doi.org/10.1099/0022-1317-71-8-1823", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-8-1823", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Plasmid DNA including the simian virus 40 (SV40) origin of replication undergoes uncontrolled, runaway replication in cos-1 cells owing to the intracellular production of SV40 large T antigen. Covalent linkage of such plasmids with human papillomavirus type 16 (HPV-16) DNA was found to prevent runaway replication. Replication control was found to be dependent on the presence of HPV-16 DNA sequences including the El open reading frame and part of the non-coding region.", }