1887

Abstract

In an earlier report, we described the construction of the genetically engineered pseudorabies virus strain 2.4N3A which does not express glycoprotein gI. Although this strain showed a strongly reduced virulence in 10-week-old seronegative pigs, it could still cause severe disease or death in 3-day-old piglets. To attenuate the strain further, we constructed mutants with a deletion in the viral thymidine kinase gene. One mutant strain, designated 783, has a deletion of 19 base pairs and was shown to be highly immunogenic and safe for vaccination of pigs against pseudorabies virus.

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/content/journal/jgv/10.1099/0022-1317-71-7-1591
1990-07-01
2020-01-21
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-71-7-1591
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