1887

Abstract

The sequence of the P (phosphoprotein) gene of mumps virus has been determined. It has two open reading frames, the first of which probably encodes the NS1 (or V) protein of mumps virus. Expression of the P protein requires the insertion of two non-templated residues to link the two ORFs in a process analogous to that observed in the P/V gene of simian virus type 5 to which mumps virus is closely related. Strain differences in the accuracy of insertion of non-templated G residues in the P/V gene transcripts have been described.

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1990-07-01
2021-10-17
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References

  1. Barrett T., Shrimpton S. B., Russell S.E.H. 1985; Nucleotide sequence of the entire coding region of canine distemper virus polymerase-associated (P) protein mRNA. Virus Research 3:3673–72
    [Google Scholar]
  2. Bellini W. J., Englund G., Rozenblatt S., Arnheiter H., Richardson C. D. 1985; Measles virus P gene codes for two proteins. Journal of Virology 53:908–919
    [Google Scholar]
  3. Campbell J. J., Cosby S. L., Scott J. K., Rima B. K., Martin S. J., Appel M. 1980; A comparison of measles and canine distemper virus polypeptides. Journal of General Virology 48:149–159
    [Google Scholar]
  4. Cattaneo R., Kaelin K., Baczko K., Billeter M. A. 1989; Measles virus editing provides an additional cysteine-rich protein.. cell 56:759–764
    [Google Scholar]
  5. Chambers P., Samson A. C. R. 1982; Non-structural proteins in Newcastle disease virus-infected cells. Journal of Virology 58:1–12
    [Google Scholar]
  6. Collins P. L., Wertz G. W., Ball L. A., Hightower L. E. 1982; Coding assignments of the five smaller mRNAs of Newcastle disease virus. Journal of Virology 43:1024–1031
    [Google Scholar]
  7. Collins P. L., Huang Y. T., Wertz G. W. 1984; Identification of a tenth mRNA of respiratory syncytial virus and assignment of polypeptides to the 10 viral genes. Journal of Virology 49:572–578
    [Google Scholar]
  8. Curran J. A., Kolakofsky D. 1988; Ribosomal initiation from an ACG codon in the Sendai P/C mRNA. EMBO Journal 7:2452–51
    [Google Scholar]
  9. Elango N., Kovamees J., Norrby E. 1989; Sequence analysis of the mumps virus mRNA encoding the P protein. Virology 162:6267
    [Google Scholar]
  10. Elliott G. D., Afzal M. A., Martin S. J., Rima B. K. 1989; Nucleotide sequences of the mumps matrix and fusion and putative SH genes and their deduced amino acid sequences. Virus Research 12:61–75
    [Google Scholar]
  11. Giorgi C., Blumberg B. M., Kolakofsky D. 1983; Sendai virus contains overlapping genes expressed from a single mRNA. Cell 35:829–836
    [Google Scholar]
  12. Herrler G., Compans R. W. 1982; Synthesis of mumps virus polypeptides in infected Vero cells. Virology 119:430–438
    [Google Scholar]
  13. Hightower L., Smith G. W., Collins P. L. 1984 How many forms of the Newcastle disease virus P protein are there? In The Molecular Biology of Negative Strand Viruses pp 301–308 Bishop D. H. L., Compans R. W. Edited by New York: Academic Press;
    [Google Scholar]
  14. Huang Y. T., Wertz G. W. 1982; The genome of respiratory syncytial virus is a negative-stranded RNA that codes for at least seven mRNA species. Journal of Virology 43:150–157
    [Google Scholar]
  15. Kolakofsky D. 1976; Isolation and characterization of Sendai virus DI-RNAs. Cell 8:547–555
    [Google Scholar]
  16. Lamb R. A., Choppin P. W. 1978; Determination by peptide mapping of the unique polypeptides in Sendai virions and infected cells. Virology 84:469–478
    [Google Scholar]
  17. Mcginnes L., Mcquaid C., Morrison T. 1988; The P protein and the non-structural 38K and 29K proteins of Newcastle disease virus are derived from the same open reading frame. Virology 164:256–264
    [Google Scholar]
  18. Peluso R. W., Lamb R. A., Choppin P. W. 1977; Polypeptide synthesis in simian virus 5-infected cells. Journal of Virology 23:177–187
    [Google Scholar]
  19. Rima B. K. 1989; Comparison of amino acid sequences of the major structural proteins of the paramyxo- and morbilliviruses. In Genetics and Pathogenicity of Negative-Strand Viruses, pp 254–263 Kolakofsky D., Mahy B. W. J. Edited by Amsterdam: Elsevier;
    [Google Scholar]
  20. Rima B. K., Martin S. J. 1979; Effect of undiluted passage on the polypeptides of measles virus. Journal of General Virology 44:1351–44
    [Google Scholar]
  21. Rima B. K., Roberts M. W., Mcadam W. D., Martin S. J. 1980; Polypeptide synthesis in mumps virus-infected cells. Journal of General Virology 46:501–505
    [Google Scholar]
  22. Rima B. K., Lappin S. A., Roberts M. W., Martin S. J. 1981; A study of phosphorylation of the measles membrane protein. Journal of General Virology 56:447–450
    [Google Scholar]
  23. Sanger F., Nicklen S., Coulson A. R. 1977; DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences U.S.A: 745463–5467
    [Google Scholar]
  24. Simpson E.J.B., Curran J. A., Martin S. J., Hoey E. M., Rima B. K. 1984; Characterization of mumps virus proteins and RNA. In The Molecular Biology of Negative-Strand Viruses, pp 333–338 Bishop D. H. L., Compans R. W. Edited by New York: Academic Press;
    [Google Scholar]
  25. Takeuchi K., Hishiyama M., Yamada A., Sugiura A. 1988; Molecular cloning and sequence analysis of the mumps virus gene encoding the P protein: mumps virus P gene is monocistronic. Journal of General Virology 69:2043–2049
    [Google Scholar]
  26. Thomas S. M., Lamb R. A., Paterson R. G. 1988; Two mRNAs that differ by two non-templated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell 54:891–902
    [Google Scholar]
  27. Vainionpaa R. 1979; Measles virus specified polypeptides in infected cells. Archives of Virology 60:239–248
    [Google Scholar]
  28. Venkatesan S., Elango N., Chanock R. M. 1983; Construction and characterization of cDNA clones for four respiratory syncytial viral genes. Proceedings of the National Academy of Sciences U.S.A: 801280–1284
    [Google Scholar]
  29. Vidal S., Curran J., Kolakofsky D. 1990; Editing of the Sendai P/C mRNA by G insertion occurs during mRNA synthesis via a virus-encoded activity. Journal of Virology 64:239–246
    [Google Scholar]
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