@article{mbs:/content/journal/jgv/10.1099/0022-1317-71-7-1497, author = "McDermott, Mark R. and Brais, Leslie J. and Evelegh, Michael J.", title = "Mucosal and systemic antiviral antibodies in mice inoculated intravaginally with herpes simplex virus type 2", journal= "Journal of General Virology", year = "1990", volume = "71", number = "7", pages = "1497-1504", doi = "https://doi.org/10.1099/0022-1317-71-7-1497", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-7-1497", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Herpes simplex virus type 2 (HSV-2) causes lethal illness after intravaginal (IVAG) inoculation into BALB/cJ mice. In the present studies, we demonstrated in mice that primary IVAG vaccination with an attenuated strain of HSV-2 induced humoral immunity in sera and in vaginal secretions. Secondary genital exposure to HSV-2 enhanced this response. However, intraperitoneal exposure to attenuated HSV-2 elicited an antiviral antibody response in sera but not in vaginal secretions. In both sera and vaginal secretions, antiviral IgG antibodies were the major isotype. Systemic exposure to HSV-2 elicited antibodies only in sera that were specific for the major viral antigens whereas IVAG inoculation with HSV-2 stimulated both serum and vaginal antibody responses. Intravenous transfer of antiviral monoclonal antibodies protected against systemic HSV-2 infection but were ineffective against vaginal infection due to a lack of transudation into vaginal secretions. These results suggested that local humoral immunity in the genital tract is important in resistance to HSV-2.", }