Mice infected with lactate dehydrogenase-elevating virus (LDV) developed antibodies reactive with a tumour cell surface antigen (TSA) of Moloney sarcoma virus (Mo-MSV)-transformed mouse cells (Sac). We demonstrate that STU mice infected with LDV were protected against growth of syngeneic Sac tumour cells as early as 23 days post-infection (p.i.) and up to 5 months p.i. Nine LDV strains, including the neurovirulent LDV-C, elicited production of anti-TSA antibodies, which were restricted to the IgM isotype. Monoclonal anti-TSA antibodies were raised 4 days after infection of STU mice with LDV. When tested against several transformants of STU and BALB/c mouse origin they were found to react with Mo-MSV transformants (PV-TC-77, STU mouse origin; MSV85 C1 3, BALB/c mouse origin), methylcholanthrene-transformed MethA cells (BALB/c origin) and L929 cells. We suggest that the well known tumour growth inhibition by LDV is due to LDV-induced anti-TSA antibodies.
BrintonM. A.,
GavinE. I.,
FernandezA. V.1986;
. Genotypic variation among six isolates of lactate dehydrogenase-elevating virus, journal of General Virology 67:2673–2684
MichaelidesM. C.,
SchlesingerS.1974; Effect of acute or chronic infection with lactic dehydrogenase virus (LDV) on the susceptibility of mice to plasmacytoma MOPC-315. Journal of Immunology 112:1560–1564
TrowbridgeI. S.,
RalphP.,
BevanM. J.1975; Differences in the surface proteins of mouse B and T cells.. Proceedings of the National Academy of Sciences U.S.A: 72157–161
WeilandE.,
MussgayM.1982; Transformed cell lines derived from progressor sarcoma virus (Moloney) induced tumours. I. Differences between C-type viruses from producer and helper virus infected nonproducer cells. Archives of Virology 71:343–347
WeilandE.,
ThielH.-J.1985; Monoclonal antibody detects a common surface antigen on two independently established murine Moloney sarcoma virus non-producer transformants. Journal of General Virology 66:1863–1872
WeilandE.,
MussgayM.,
WeilandF.1978; Nonproducer malignant tumour cells with rescuable sarcoma virus genome isolated from a recurred Moloney sarcoma. Journal of Experimental Medicine 148:408–423