1887

Abstract

Mice infected with lactate dehydrogenase-elevating virus (LDV) developed antibodies reactive with a tumour cell surface antigen (TSA) of Moloney sarcoma virus (Mo-MSV)-transformed mouse cells (Sac). We demonstrate that STU mice infected with LDV were protected against growth of syngeneic Sac tumour cells as early as 23 days post-infection (p.i.) and up to 5 months p.i. Nine LDV strains, including the neurovirulent LDV-C, elicited production of anti-TSA antibodies, which were restricted to the IgM isotype. Monoclonal anti-TSA antibodies were raised 4 days after infection of STU mice with LDV. When tested against several transformants of STU and BALB/c mouse origin they were found to react with Mo-MSV transformants (PV-TC-77, STU mouse origin; MSV85 C1 3, BALB/c mouse origin), methylcholanthrene-transformed MethA cells (BALB/c origin) and L929 cells. We suggest that the well known tumour growth inhibition by LDV is due to LDV-induced anti-TSA antibodies.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-71-5-1233
1990-05-01
2022-10-07
Loading full text...

Full text loading...

/deliver/fulltext/jgv/71/5/JV0710051233.html?itemId=/content/journal/jgv/10.1099/0022-1317-71-5-1233&mimeType=html&fmt=ahah

References

  1. Aaronson S. A., Rowe W. P. 1970; Nonproducer clones of murine sarcoma transformed BALB/3T3 cells. Virology 42:9–19
    [Google Scholar]
  2. Brinton M. A., Gavin E. I., Fernandez A. V. 1986; . Genotypic variation among six isolates of lactate dehydrogenase-elevating virus, journal of General Virology 67:2673–2684
    [Google Scholar]
  3. Grossmann A., Weiland F., Weiland E. 1989; Autoimmunity induced by lactate dehydrogenase-elevating virus (LDV): monoclonal antibodies against Golgi antigens and other subcellular elements. Autoimmunity 2:201–211
    [Google Scholar]
  4. Hakomori S.-J. 1984; Tumour associated carbohydrate antigens. Annual Review of Immunology 2:103–126
    [Google Scholar]
  5. Isakov N., Feldman M., Segal S. 1981; Effect of lactic dehydrogenase virus infection on tumour induction and tumour growth. Cancer Research 41:667–672
    [Google Scholar]
  6. Michaelides M. C., Schlesinger S. 1974; Effect of acute or chronic infection with lactic dehydrogenase virus (LDV) on the susceptibility of mice to plasmacytoma MOPC-315. Journal of Immunology 112:1560–1564
    [Google Scholar]
  7. Riley V., Lilly F., Huerto E., Bardell D. 1960; Transmissible agent associated with 26 types of experimental mouse neoplasms. Science 132:545–547
    [Google Scholar]
  8. Rowson K. E. K., Mahy B. W. J. 1985; Lactate dehydrogenase-elevating virus. Journal of Genera! Virology 66:2297–2312
    [Google Scholar]
  9. Trowbridge I. S., Ralph P., Bevan M. J. 1975; Differences in the surface proteins of mouse B and T cells.. Proceedings of the National Academy of Sciences U.S.A: 72157–161
    [Google Scholar]
  10. Weiland E., Mussgay M. 1982; Transformed cell lines derived from progressor sarcoma virus (Moloney) induced tumours. I. Differences between C-type viruses from producer and helper virus infected nonproducer cells. Archives of Virology 71:343–347
    [Google Scholar]
  11. Weiland E., Thiel H.-J. 1985; Monoclonal antibody detects a common surface antigen on two independently established murine Moloney sarcoma virus non-producer transformants. Journal of General Virology 66:1863–1872
    [Google Scholar]
  12. Weiland E., Mussgay M., Weiland F. 1978; Nonproducer malignant tumour cells with rescuable sarcoma virus genome isolated from a recurred Moloney sarcoma. Journal of Experimental Medicine 148:408–423
    [Google Scholar]
  13. Weiland E., Weiland F., Grossmann A. 1987; Lactate dehydrogenase-elevating virus induces anti-Golgi apparatus antibodies. Journal of General Virology 68:1983–1991
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-71-5-1233
Loading
/content/journal/jgv/10.1099/0022-1317-71-5-1233
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error