RT Journal Article SR Electronic(1) A1 Spies, U. A1 Müller, H.YR 1990 T1 Demonstration of enzyme activities required for cap structure formation in infectious bursal disease virus, a member of the birnavirus group JF Journal of General Virology, VO 71 IS 4 SP 977 OP 981 DO https://doi.org/10.1099/0022-1317-71-4-977 PB Microbiology Society, SN 1465-2099, AB The putative viral transcriptase p90 in infectious bursal disease virus (IBDV) was shown to form an enzyme- guanylate intermediate which is indicative of guanylyl- transferase activity. The p90-nucleotide bond is most likely to be a phosphodiester linkage, as it resisted treatment with HC1 and NH2OH but was sensitive to NaOH. This is in contrast to phosphoamide bonds formed by reovirus cores. Methyltransferase activity was also demonstrated in IBDV, and is closely associated with transcription, suggesting that p90 may be a multifunctional enzyme., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-4-977