1887

Abstract

Sera from 75 patients with warts were tested for antibodies against human papillomaviruses (HPVs) in an immunoelectron microscopy test. A group of 40 patients’ sera were tested against a pooled suspension of the HP Vs extracted from their warts and 90% of the sera were found to be antibody-positive. Prior to serological investigation viruses from a second group of 35 patients were typed by dot blot hybridization with HPV-1 and HPV-2 DNA. According to these results the patients were divided into type 1, type 2 and non-1, non-2 virus carriers. Sera of these patients were first tested for antibodies reactive with their homologous viruses and then for antibodies against type 1 virus. More than 80% of the patients possessed antibodies against their homologous viruses, but only a small minority of sera from type 2 and non-1, non-2 virus carriers were reactive with type 1 viruses. These results suggest that the antibody reactive in the immuno- aggregation test is type-specific.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-71-2-419
1990-02-01
2022-10-06
Loading full text...

Full text loading...

/deliver/fulltext/jgv/71/2/JV0710020419.html?itemId=/content/journal/jgv/10.1099/0022-1317-71-2-419&mimeType=html&fmt=ahah

References

  1. Almeida J. D., Goffe A. P. 1965; Antibody to wart virus in human sera demonstrated by electron microscopy and precipitin test. Lancet ii:1205–1207
    [Google Scholar]
  2. Genner J. 1971; Verrucae vulgares II. Demonstration of a complement fixation reaction. Acta dermato-veneroiogica 51:365–373
    [Google Scholar]
  3. Goffe A., Almeida J., Brown F. 1966; Further information on the antibody response to wart virus. Lancet ii:607–609
    [Google Scholar]
  4. Jenison S. A., Firtzlaff J. M., Langenberg A., Galloway D. A. 1988; Identification of immunoreactive antigens of human papillomavirus type 6b by using Escherichia coli-expressed fusion proteins. Journal of Virology 62:2115–2123
    [Google Scholar]
  5. Kienzler J. L., Lemoine M. T., Orth G., Jibard N., Blanc D., Laurent R., Agache P. 1983; Humoral and cell-mediated immunity to human papillomavirus type 1 (HPV-1) in human warts. British Journal of Dermatology 108:665–672
    [Google Scholar]
  6. McCombs R. M., Benyesh-Melnick M., Brunschwig J. P. 1966; Biophysical studies of vesicular stomatitis virus. Journal of Bacteriology 91:803–812
    [Google Scholar]
  7. Pass F., Maizel J. V.JR 1973; Wart-associated antigens. II. Human immunity to viral structural proteins. Journal of Investigative Dermatology 60:307–311
    [Google Scholar]
  8. Pfister H., Zur Hausen H. 1978; Seroepidemiological studies of human papilloma virus (HPV-1) infections. International Journal of Cancer 21:161–165
    [Google Scholar]
  9. Pyrhönen S. 1978; Human wart-virus antibodies in patients with genital and skin warts. Acta dermato-veneroiogica 58:427–432
    [Google Scholar]
  10. Pyrhönen S., Johansson E. 1975; Regression of warts. An immunological study. Lancet i:592–595
    [Google Scholar]
  11. Rigby P. W. J., Dieckmann M., Rhodes C., Berg P. 1977; Labelling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. Journal of Molecular Biology 113:237–252
    [Google Scholar]
  12. Spradbrow P. B. 1987; Immune response to papillomavirus infection. In Papillomaviruses and Human Disease pp. 334–370 Syrjänen K., Gissmann L., Koss L. G. Edited by Wien & New York: Springer-Verlag;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-71-2-419
Loading
/content/journal/jgv/10.1099/0022-1317-71-2-419
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error