@article{mbs:/content/journal/jgv/10.1099/0022-1317-71-2-281, author = "Kawano, Hiroshi and Mifune, Kumato and Ohuchi, Masanobu and Mannen, Kazuaki and Cho, Shuichi and Hiramatsu, Kazufumi and Shichijo, Akehisa", title = "Protection against rabies in mice by a cytotoxic T cell clone recognizing the glycoprotein of rabies virus", journal= "Journal of General Virology", year = "1990", volume = "71", number = "2", pages = "281-287", doi = "https://doi.org/10.1099/0022-1317-71-2-281", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-2-281", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "By the use of liposomes containing the purified surface glycoprotein (G) of rabies virus and the haemagglu- tinin-neuraminidase (HN) and fusion (F) glycoproteins of Sendai virus, the target antigen of anti-rabies virus cytotoxic T lymphocyte (CTL) clones isolated in a previous study was identified as the G protein. Recognition of the H-2K determinant of the class I major histocompatibility complex (MHC) was necessary for target lysis by the CTL clones. One of the CTL clones was examined for the ability to protect mice against a lethal rabies virus infection. CTL were transferred into syngeneic mice which had been infected in the hind footpad with the ERA strain of rabies virus. The infection was converted into a lethal infection by cyclophosphamide treatment 1 day after virus infection. Transfer of CTL 2 to 3 days after virus infection protected approximately 50% of mice during the observation period of 4 weeks. Greater protection was obtained in mice receiving both anti-rabies virus antibodies and CTL cells.", }