1887

Abstract

By the use of liposomes containing the purified surface glycoprotein (G) of rabies virus and the haemagglu- tinin-neuraminidase (HN) and fusion (F) glycoproteins of Sendai virus, the target antigen of anti-rabies virus cytotoxic T lymphocyte (CTL) clones isolated in a previous study was identified as the G protein. Recognition of the H-2K determinant of the class I major histocompatibility complex (MHC) was necessary for target lysis by the CTL clones. One of the CTL clones was examined for the ability to protect mice against a lethal rabies virus infection. CTL were transferred into syngeneic mice which had been infected in the hind footpad with the ERA strain of rabies virus. The infection was converted into a lethal infection by cyclophosphamide treatment 1 day after virus infection. Transfer of CTL 2 to 3 days after virus infection protected approximately 50% of mice during the observation period of 4 weeks. Greater protection was obtained in mice receiving both anti-rabies virus antibodies and CTL cells.

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1990-02-01
2024-03-29
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References

  1. Baer G. M., Yager P. A. 1977; A mouse model for rabies postexposure rabies prophylaxis, the comparative efficacy of two vaccines and of antiserum administration. Journal of General Virology 36:51–58
    [Google Scholar]
  2. Bennink J. R., Yewdell J. W., Smith G. L., Moss B. 1987; Antiinfluenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a non-structural protein responsiveness to individual viral antigens is major histocompatibility complex controlled. Journal of Virology 61:1098–1102
    [Google Scholar]
  3. Celis E., Wiktor T. J., Dietzschold B., Koprowski H. 1985; Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen-specific antibodies. Journal of Virology 56:426–433
    [Google Scholar]
  4. Cho S., Narahara H., Mifune K., Kawai A. 1987; Murine T cell clones directed to rabies virus: isolation and some of their properties. Journal of General Virology 68:1115–1123
    [Google Scholar]
  5. Dietzschold B., Wang H., Rupprecht C. E., Celis E., Tollis M., Ertl H., Heber-Katz E., Koprowski H. 1987; Induction of protective immunity against rabies by immunization with rabies virus ribonucleoprotein. Proceedings of the National Academy of Sciences, U.S.A 84:9165–9169
    [Google Scholar]
  6. Donohue J. H., Rosenberg S. A. 1983; The fate of interleukin-2 after in vivo administration. Journal of Immunology 130:2203–2208
    [Google Scholar]
  7. Gillis S., Ferm M. M., Ou W., Smith K. A. 1978; T-cell growth factor: parameters of production and a quantitative microassay for activity. Journal of Immunology 120:2027–2037
    [Google Scholar]
  8. Hale A. H., Ruebush M. J., LeFrancois L. 1981; Cross-reactive anti-vesicular stomatitis virus (VSV) cytotoxic T lymphocytes recognize the major surface glycoprotein of VSV. European Journal of Immunology 11:434–436
    [Google Scholar]
  9. Halonen P. E., Murphy F. A., Fields B. N., Reese D. R. 1968; Hemagglutination of rabies and some other bullet-shaped viruses. Proceedings of the Society for Experimental Biology and Medicine 127:1037–1042
    [Google Scholar]
  10. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature; London: 227680–685
    [Google Scholar]
  11. Lodmell D. L., Ewalt L. C. 1987; Immune sera and antiglycoprotein monoclonal antibodies inhibit in vitro cell-to-cell spread of pathogenic rabies viruses. Journal of Virology 61:3314–3318
    [Google Scholar]
  12. Mannen K., Ohuchi M., Mifune K. 1982; pH-dependent hemolysis and cell fusion of rhabdoviruses. Microbiology and Immunology 25:1035–1043
    [Google Scholar]
  13. Mifune K., Shichijo A., Makino Y., Takeuchi E., Yamada A., Sakamoto K. 1980; A mouse model for the pathogenesis and postexposure prophylaxis of rabies. Microbiology and Immunology 24:835–845
    [Google Scholar]
  14. Mifune K., Takeuchi E., Napiorkowski P. A., Yamada A., Sakamoto K. 1981; Essential role of T cells in the post-exposure prophylaxis of rabies in mice. Microbiology and Immunology 25:895–904
    [Google Scholar]
  15. Miller A., Morse H. C. III Winkelstein J., Nathanson N. 1978; The role of antibody in recovery from experimental rabies. I. Effect of depletion of B and T cells. Journal of Immunology 121:321–326
    [Google Scholar]
  16. Murphy F. A., Bauer S. P., Harrison A. K., Winn W. C. JR 1973; Comparative pathogenesis of rabies and rabies-like viruses; viral infection and transit from inoculation site to the central nervous system. Laboratory Investigation 28:361–376
    [Google Scholar]
  17. Puddington L., Bevan M. J., Rose J. K., LeFrancois L. 1986; N protein is the predominant antigen recognized by vesicular stomatitis virus specific cytotoxic T cells. Journal of Virology 60:708–717
    [Google Scholar]
  18. Sikes R. K., Cleary W. F., Koprowski H., Wiktor T. J., Kaplan M. M. 1971; Effective protection of monkeys against death from street virus by post-exposure administration of tissue culture rabies vaccine. Bulletin of the World Health Organization 45:1–11
    [Google Scholar]
  19. Smith J. S. 1981; Mouse model for abortive rabies infection of the central nervous system. Infection and Immunity 31:297–308
    [Google Scholar]
  20. Stitz L., Huang R. T. C., Hengartner H., Rott R., Zinkernagel R. M. 1985; Cytotoxic T cell lysis of target cells fused with liposomes containing influenza virus haemagglutinin and neuraminidase. Journal of General Virology 66:1333–1339
    [Google Scholar]
  21. Taylor P. M., Askonas B. A. 1986; Influenza nucleoprotein- specific cytotoxic T-cell clones are protective in vivo . Journal of Immunology 58:417–420
    [Google Scholar]
  22. Townsend A. R., Skehel J. J. 1984; The influenza virus nucleoprotein gene controls the induction of both subtype-specific and cross-reactive T cells. Journal of Experimental Medicine 160:552–563
    [Google Scholar]
  23. Whitton J. L., Southern P. J., Oldstone M. B. A. 1988; Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus. Virology 162:321–327
    [Google Scholar]
  24. Wiktor T. J. 1978; Cell-mediated immunity and post-exposure protection from rabies by inactivated vaccines of tissue culture origin. In Developments in Biological Standardization 40 pp. 256–264 Hennessen W., Regamey R. H. Edited by Basel: S.Karger;
    [Google Scholar]
  25. Wraith D. C., Vessey A. E., Askonas B. A. 1987; Purified influenza virus nucleoprotein protects mice from lethal infection. Journal of General Virology 68:433–440
    [Google Scholar]
  26. Yewdell J. W., Bennick J. R., Smith G. L., Moss B. 1985; Influenza A virus nucleoprotein is a major target antigen for crossreactive anti-influenza A virus cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences, U.S.A 82:1785–1789
    [Google Scholar]
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