RT Journal Article SR Electronic(1) A1 Tüth, Ferenc D. A1 Nrskov-Lauritsen, Niels A1 Juhl, Claus B. A1 Aboagye-Mathiesen, George A1 Ebbesen, PeterYR 1990 T1 Interferon Production by Cultured Human Trophoblasts and Choriocarcinoma Cell Lines Induced by Sendai Virus JF Journal of General Virology, VO 71 IS 12 SP 3067 OP 3069 DO https://doi.org/10.1099/0022-1317-71-12-3067 PB Microbiology Society, SN 1465-2099, AB Human term-placental trophoblasts in primary culture were studied for an interferon (IFN) response when challenged with Sendai virus and compared to three choriocarcinoma cell lines, placental fibroblasts and placental macrophages. Normal trophoblasts were high producers and released both IFN-α and IFN-β. In contrast, one choriocarcinoma cell line was a low producer and all malignant lines produced only IFN-β. Circulating monocytes produce IFN-α but placental macrophages secreted IFN-β and some IFN-α, suggesting that IFN production may be dependent on the stage of differentiation. A role for trophoblast IFNs in protection of the foetus against virus infections is proposed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-12-3067