1887

Abstract

Short chain fatty acids inhibit the replication of bovine enterovirus but are almost ineffective against poliovirus type 1, coxsackievirus B5, encephalomyocarditis virus and human rhinovirus 1B. Lauric acid binds to bovine enterovirus, thereby stabilizing the virus particle to heat degradation. Fatty acid-bound virions attach to susceptible cells but fail to undergo cell-mediated uncoating. The inhibitory effect is reversible with chloroform and may result from a hydrophobic interaction between the fatty acid and a specific site on the virus particle.

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1990-10-01
2022-08-16
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References

  1. Brown F., Cartwright B. 1963; Purification of radioactive foot- and-mouth disease virus. Nature; London: 1991169–1170
    [Google Scholar]
  2. Chow M., Newman J. F. E., Filman D., Hogle J. M., Rowlands D. J., Brown F. 1987; Myristylation of picomavirus capsid protein VP4 and its structural significance. Nature; London: 327482–486
    [Google Scholar]
  3. Diana G. D., Salvador U. J., Zulay E. S., Johnson R. E., Collins J. C., Johnson D., Hinshaw W. B., Lorenz R. R., Thielking W. H., Pancic F. 1977; Antiviral activity of some β-diketones. I. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses. Journal of Medicinal Chemistry 20:750–756
    [Google Scholar]
  4. Everaert L., Vrijsen R., Boeyé A. 1989; Eclipse products of poliovirus after cold-synchronized infection of HeLa cells. Virology 171:76–82
    [Google Scholar]
  5. Ishutsuka H., Ninomiya Y., Ohsawa C., Fujiu M., Suhara Y. 1982; Direct and specific inactivation of rhinovirus by a chalcone, Ro 09–0410. Antimicrobial Agents and Chemotherapy 22:617–621
    [Google Scholar]
  6. Kenny M. T., Torney H. L., Dulworth J. K. 1988; Mechanism of action of the antiviral compound MDL 20,610. Antiviral Research 9:249–261
    [Google Scholar]
  7. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature; London: 227680–685
    [Google Scholar]
  8. Lonberg-Holm K., Noble-Harvey J. 1973; Comparison of in vitro and cell-mediated alteration of a human rhinovirus and its inhibition by sodium dodecyl sulphate. Journal of Virology 12:819–826
    [Google Scholar]
  9. Lonberg-Holm K., Gosser L. B., Kauer J. C. 1975; Early alteration of poliovirus in infected cells and its specific inhibition. Journal of General Virology 27:329–342
    [Google Scholar]
  10. Mcferran J. B. 1962; Bovine enteroviruses. Annals of the New York Academy of Sciences 101:436–443
    [Google Scholar]
  11. Mcsharry J. J., Caliguiri L. A., Eggers H. J. 1979; Inhibition of uncoating of poliovirus by Arildone, a new antiviral drug. Virology 97:307–315
    [Google Scholar]
  12. Ninomiya Y., Ohsawa C., Aoyama M., Umeda I., Suhara Y., Ishutsuka H. 1984; Antivirus agent, Ro 09–0410, binds to rhinovirus specifically and stabilizes the virus conformation. Virology 134:269–276
    [Google Scholar]
  13. Otto M. J., Fox M. P., Fancher M. J., Kuhrt M. F., Diana G. D., Mckinley M. A. 1985; In vitro activity of WIN 51711, a new broad-spectrum anti-picornavirus drug. Antimicrobial Agents and Chemotherapy 27:883–886
    [Google Scholar]
  14. Paul A. V., Schultz A., Pincus S. E., Oroszlan S., Wimmer E. 1987; Capsid protein VP4 of poliovirus is N-myristoylated. Proceedings of the National Academy of Sciences U.S.A: 847827–7831
    [Google Scholar]
  15. Rossmann M. G. 1989; The structure of antiviral agents that inhibit uncoating when complexed with viral capsids. Antiviral Research 11:3–14
    [Google Scholar]
  16. Smith T. J., Kremer M. J., Lou M., Vriend G., Arnold E., Kamer G., Rossmann M. G., Mckinley M. A., Diana G. D., Otto M. J. 1986; The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science 233:1286–1293
    [Google Scholar]
  17. Tisdale M., Selway J. W. T. 1984; Effect of dichloroflavan (BW683C) on the stability and uncoating of rhinovirus type IB. Journal of Antimicrobial Chemotherapy 14:97–105
    [Google Scholar]
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