1887

Abstract

Summary

Seven temperature-sensitive (ts) mutants of Abelson murine leukaemia virus (A-MuLV) were isolated on the basis of the temperature dependence of their soft agar colony-forming ability. These seven ts mutants exhibited similar characteristics and were not ts for morphological transformation and autophosphorylation of P120 protein. The dissociation of the properties of morphology, soft agar colony formation and tyrosine kinase activity might suggest that the v- product has more than one primary intracellular target.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-70-9-2527
1989-09-01
2022-08-15
Loading full text...

Full text loading...

/deliver/fulltext/jgv/70/9/JV0700092527.html?itemId=/content/journal/jgv/10.1099/0022-1317-70-9-2527&mimeType=html&fmt=ahah

References

  1. Abelson H. T., Rabstein L. S. 1970; Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer Research 30:2213–2222
    [Google Scholar]
  2. Anderson D. D., Beckmann R. P., Harms E. H., Nakamura K., Weber M. J. 1981; Biological properties of ‘partial’ transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase. Journal of Virology 37:445–158
    [Google Scholar]
  3. Becker D., Kurth R., Critchley D., Friis R., Bauer H. 1977; Distinguishable transformation-defective phenotypes among temperature-sensitive mutants of Rous sarcoma virus. Journal of Virology 21:1042–1055
    [Google Scholar]
  4. Engelman A., Rosenberg N. 1987; Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis. Proceedings of the National Academy of SciencesU.S.A. 84:8021–8025
    [Google Scholar]
  5. Fischinger P. J., Nomura S., Bolognesi D. P. 1975; A novel murine oncornavirus with dual eco- and xenotropic properties. Proceedings of the National Academy of SciencesU.S.A. 72:5150–5155
    [Google Scholar]
  6. Garber E. A., Krueger J. G., Hanafusa H., Goldberg A. R. 1983; Temperature-sensitive membrane association of pp60src in tsNY68-infected cells correlates with increased tyrosine phosphorylation of membrane-associated proteins. Virology 126:73–86
    [Google Scholar]
  7. Kipreos E. T., Lee J. G., Wang J. Y. J. 1987; Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine. Proceedings of the National Academy of SciencesU.S.A. 84:1345–1349
    [Google Scholar]
  8. Maeda T., Owada M. K., Sugiyama H., Miyake S., Tani Y., ogawa h., Oka Y., Komori T., Soma T., Kishimoto S., Seki J., Sakato N., Hakura A. 1987; Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product. Cell Differentiation 20:263–269
    [Google Scholar]
  9. Rosenberg R, Baltimore d., Scher C. D. 1975; In vitro transformation of lymphoid cells by Abelson murine leukemia virus. Proceedings of the National Academy of SciencesU.S.A 72:1932–1936
    [Google Scholar]
  10. Scher C. D., Siegler R. 1975; Direct transformation of 3T3 cells by Abelson murine leukaemia virus. Nature London: 253729–731
    [Google Scholar]
  11. Stoker A. W., Enrietto P. I., Wyke J. A. 1984; Functional domains of the pp60v-src protein as revealed by analysis of temperature-sensitive Rous sarcoma virus mutants. Molecular and Cellular Biology 4:1508–1514
    [Google Scholar]
  12. Sugiyama H., Akira S., Yoshida N., Kishimoto S., Yamamura Y., Kincade P., Honjo T., Kishimoto T. 1982; Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines. Journal of Immunology 126:2793–2797
    [Google Scholar]
  13. Takemori T., Miyazoe I., Shirasawa T., Taniguchi M., Graf T. 1987; A temperature-sensitive mutant of Abelson murine leukemia virus confers inducibility of IgM expression to transformed lymphoid cells. EMBO Journal 6:951–956
    [Google Scholar]
  14. Weber M. J., Friis R. R. 1979; Dissociation of transformation parameters using temperature-conditional mutants of Rous sarcoma virus. Cell 16:25–32
    [Google Scholar]
  15. Witte O. N., Dasgupta A., Baltimore D. 1980; Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature London: 283826–831
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-70-9-2527
Loading
/content/journal/jgv/10.1099/0022-1317-70-9-2527
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error