1887

Abstract

Summary

The DNA hypomethylating agent 5-azacytidine greatly increased the reactivation of alphaherpesvirus saimiri-1 (HVS) from latently infected rabbit dorsal root ganglia, although it inhibited the virus yield and plaque formation efficiency of HVS in Vero cells. 12--Tetradecanoylphorbol 13-acetate(a protein kinase C activator) and sodium -butyrate both had a stimulating action on replication in Vero cells but did not affect the release of HVS from latently infected rabbit dorsal root ganglia.

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1989-09-01
2021-10-21
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References

  1. Ash R. J. 1986; Butyrate-induced reversal of herpes simplex virus restriction in neuroblastoma cells. Virology 155:584–592
    [Google Scholar]
  2. Ben-Hattar J., Jiricny J. 1988; Methylation of single CpG dinucleotides within a promoter element of the herpes simplex virus tk gene reduces its transcription in vivo. Gene 65:219–227
    [Google Scholar]
  3. Bernstein D. I., Kappes J. C. 1988; Enhanced in vitro reactivation of latent herpes simplex virus from neural and peripheral tissues with hexamethylenebisacetamide. Archives of Virology 99:57–65
    [Google Scholar]
  4. Bohan C., York D., Srinivasan A. 1987; Sodium butyrate activates human immunodeficiency virus long terminal repeat-directed expression. Biochemical and Biophysical Research Communications 148:899–905
    [Google Scholar]
  5. Chiu R., Imagawa M., Imbra R. J., Bockoven J. R., Karin M. 1987; Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature London: 329648–651
    [Google Scholar]
  6. Clough D. W., Kunkel L. M., Davidson R. L. 1982; 5-Azacytidine-induced reactivation of a herpes simplex thymidine kinase gene. Science 216:70–73
    [Google Scholar]
  7. Darville J. M. 1983; A miniaturised and simplified technique for typing and subtyping herpes simplex virus. Journal of Clinical Pathology 36:929–934
    [Google Scholar]
  8. Desrosiers R. C., Mulder C., Fleckenstein B. 1979; Methylation of herpesvirus saimiri DNA in lymphoid tumor cell lines. Proceedings of the National Academy of SciencesU.S.A. 76:3839–3843
    [Google Scholar]
  9. Doerfler W. 1983; DNA methylation and gene activity. Annual Review of Biochemistry 52:93–124
    [Google Scholar]
  10. Dressler G. R., Rock D. L., Fraser N. W. 1987; Latent herpes simplex virus type 1 DNA is not extensively methylated in vivo. Journal of General Virology 68:1761–1765
    [Google Scholar]
  11. Harada S., Koyanagi Y., Nakashima H., Kobayashi N., Yamamoto N. 1986; Tumor promoter, TPA, enhances replication of HTLV-III/LAV. Virology 154:249–258
    [Google Scholar]
  12. Hino M., Sekizawa T. 1986; Enhanced in vitro reactivation of herpes simplex virus by n-butyrate from latently infected trigeminal ganglia. Igakuno Ayumi 136:617–618
    [Google Scholar]
  13. Iseki S., Baserga R. 1983; Effect of butyrate on adenovirus infection in semipermissive cells. Virology 124:188–191
    [Google Scholar]
  14. Kolata G. 1985; Fitting methylation into development. Science 228:1183–1184
    [Google Scholar]
  15. Kruh J. 1982; Effects of sodium butyrate, a new pharmacological agent on cells in culture. Molecular and Cellular Biochemistry 42:65–82
    [Google Scholar]
  16. Laux G., Freese U. K., Fischer R., Polack A., Kofler E., Bornkamm G. W. 1988; TPA-inducible Epstein-Barr virus genes in Raji cells and their regulation. Virology 162:503–507
    [Google Scholar]
  17. Leder A., Leder P. 1975; Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells. Cell 5:319–322
    [Google Scholar]
  18. Leib D. A., Hart C. A., Mccarthy K. 1987; Characterization of four herpesviruses isolated from owl monkeys and their comparison with Herpesvirus saimiri type 1 (Herpesvirus tamarinus) and herpes simplex virus type 1. Journal of Comparative Pathology 97:159–169
    [Google Scholar]
  19. Leib D. A., Hart C. A., Mccarthy K. 1988; Alphaherpesvirus saimiri in rabbits: a model for human encephalitis?. Journal of General Virology 69:1609–1615
    [Google Scholar]
  20. Luka J., Kallin B., Klein G. 1979; Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate. Virology 94:228–231
    [Google Scholar]
  21. Nishtzuka Y. 1984; The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature London: 308693–698
    [Google Scholar]
  22. Nishizuka Y. 1986; Studies and perspectives of protein kinase C. Science 233:305–312
    [Google Scholar]
  23. Reichman M., Penman S. 1973; The mechanism of inhibition of protein synthesis by 5-azacytidine in HeLa cells. Biochimica et biophysica acta 324:282–289
    [Google Scholar]
  24. Saemundsen A. K., Kallin B., Klein G. 1980; Effect of n-butyrate on cellular and viral DNA synthesis in cells latently infected with Epstein-Barr virus. Virology 107:557–561
    [Google Scholar]
  25. Sanes J. R., Okun L. M. 1972; Induction of DNA synthesis in cultured neurons by ultraviolet light or methyl methane sulfonate. Journal of Cell Biology 53:587–590
    [Google Scholar]
  26. Schneider F. H. 1976; Effects of sodium butyrate on mouse neuroblastoma cells in culture. Biochemical Pharmacology 25:2309–2317
    [Google Scholar]
  27. Sharma S., Biswal N. 1977; Studies on the in vivo methylation of replicating herpes simplex virus type 1 DNA. Virology 82:265–274
    [Google Scholar]
  28. Stephanopoulos D. E., Kappes J. C., Bernstein D. I. 1988; Enhanced in vitro reactivation of herpes simplex virus type 2 from latently infected guinea-pig neural tissues by 5-azacytidine. Journal of General Virology 69:1079–1083
    [Google Scholar]
  29. Taylor S. M., Jones P. A. 1982; Mechanism of action of eukaryotic DNA mcniyltransferase. Use of 5- azacytosine-containing DNA. Journal of Molecular Biology 162:679–692
    [Google Scholar]
  30. Tosolini F., Mccarthy K., Bartzokas C. A., Lee S., Hart C. A., Baker B. F. 1981; Simian herpesviruses in rabbits: a model for prolonged latency?. In The Human Herpesviruses: An Interdisciplinary Perspective622 Nahmias A. J., Dowdle W. R., Schinazi R. F. Amsterdam New York: Elsevier;
    [Google Scholar]
  31. Tosolini F. A., Mccarthy K., Baker B. F. 1982; Studies of herpes virus latency in the sensory spinal ganglia of rabbits. Journal of Hygiene 89:421–437
    [Google Scholar]
  32. Wawra E., Pockl E., Mullner E., Wintersberger E. 1981; Effect of sodium butyrate on induction of cellular and viral DNA syntheses in polyoma virus-infected mouse kidney cells. Journal of Virology 38:973–981
    [Google Scholar]
  33. Whitby A. J., Blyth W. A., Hill T. J. 1987; The effect of DNA hypomethylating agents on the reactivation of herpes simplex virus from latently infected mouse ganglia in vitro. Archives of Virology 97:137–144
    [Google Scholar]
  34. Yamamoto N. 1984; Interaction of viruses with tumour promoters. Reviews of Physiology, Biochemistry and Pharmacology 101:111–159
    [Google Scholar]
  35. Youssoufian H., Hammer S. M., Hirsch M. S., Mulder C. 1982; Methylation of the viral genome in an in vitro model of herpes simplex virus latency. Proceedings of the National Academy of SciencesU.S.A. 79:2207–2210
    [Google Scholar]
  36. Zur hausen H. , O’Neill F. J., Freese U. K. 1978; Persisting oncogenic herpesvirus induced by the tumour promoter TPA. Nature London: 272373–375
    [Google Scholar]
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