A Herpes Simplex Virus Type 1 Mutant Containing a Deletion within Immediate Early Gene 1 Is Latency-competent in Mice

References

1. Brown S. M., Ritchie D. A., Subak-sharpe J. H. 1973; Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map. Journal of General Virology 18:329–346
   [Google Scholar]
2. Clements C. B., Subak-sharpe J. H. 1983; Recovery of herpes simplex virus 1 ts mutants from the dorsal root ganglia of mice. Progress in Brain Research 59:203–208
   [Google Scholar]
3. Clements G. B., Subak-sharpe J. H. 1988; Herpes simplex virus type 2 establishes latency in the mouse footpad. Journal of General Virology 69:375–383
   [Google Scholar]
4. Everett R. D. 1984; Transactivation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO Journal 3:3135–3141
   [Google Scholar]
5. Everett R. D. 1987; The regulation of viral and cellular genes by herpesvirus immediate-early gene products. Anticancer Research 7:589–604
   [Google Scholar]
6. Gelman I. H., Silverstein S. 1985; Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proceedings of the National Academy of SciencesU.S.A 82:5265–5269
   [Google Scholar]
7. Javier R. T., Stevens J. G., Dissette V. B., Wagner E. K. 1988; A herpes simplex virus transcript abundant in latently infected neurons is dispensable for the establishment of the latent state. Virology 166:254–257
   [Google Scholar]
8. Lieb D. A., Coen D. M., Bogard C. L., Hicks K. A., Yager D. R., Knipe D. M., Tyler K. L., Schaffer P. A. 1989; Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. Journal of Virology 63:759–768
   [Google Scholar]
9. Macpherson I., Stoker M. 1962; Polyoma transformation of hamster cell clones - an investigation of factors affecting cell competence. Virology 16:147–151
   [Google Scholar]
10. O’hare P., Hayward G. S. 1985; Three traws-acting regulatory proteins of herpes simplex virus immediate-early gene expression in a pathway involving positive and negative feedback regulation. Journal of Virology 56:723–733
    [Google Scholar]
11. Puga A., Notkins A. L. 1987; Continued expression of a poly(A)⁺ transcript of herpes simplex virus type 1 in the trigeminal ganglia of latently infected mice. Journal of Virology 61:1700–1703
    [Google Scholar]
12. Quinlan M. P., Knipe D. M. 1985; Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Molecular and Cellular Biology 5:957–963
    [Google Scholar]
13. Rock D. L., Nesburn A. B., Ghiasi H., Ong J., Lewis T. L., Lokensgard J. R., Wechsler S. L. 1987; Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. Journal of Virology 61:3820–3826
    [Google Scholar]
14. Russell J., Preston C. M. 1986; An in vitro latency system for herpes simplex virus type 2. Journal of General Virology 67:397–403
    [Google Scholar]
15. Russell J., Stow N. D., stow E. C., Preston C. M. 1987; Herpes simplex virus genes involved in latency in vitro . Journal of General Virology 68:3009–3018
    [Google Scholar]
16. Sacks W. R., Schaffer P. A. 1987; Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICPO exhibit impaired growth in cell culture. Journal of Virology 61:829–839
    [Google Scholar]
17. Spivack J. G., Fraser N. W. 1987; Detection of herpes simplex virus type 1 transcripts during latent infection in mice. Journal of Virology 61:3841–3847
    [Google Scholar]
18. Stevens J. G., Wagner E. K., Devi-rao G. B., Cook M. L., Feldman L. T. 1987; RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235:1056–1059
    [Google Scholar]
19. Stow E. C., Stow N. D. 1989; Complementation of a herpes simplex virus type 1 Vmwl 10 deletion mutant by human cytomegalovirus. Journal of General Virology 70:695–704
    [Google Scholar]
20. Stow N. D., Stow E. C. 1986; Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmwl 10. Journal of General Virology 67:2571–2585
    [Google Scholar]
21. Taha M. Y., Brown S. M., Clements G. B. 1988; Neurovirulence of individual plaque stocks of herpes simplex virus type 2 strain HG52. Archives of Virology 103:15–25
    [Google Scholar]
22. Taha M. Y., Clements G. B., Brown S. M. 1989; A variant of herpes simplex virus type 2 strain HG52 with a 1·5 kb deletion in R_L between 0 to 0·02 and 0·81 to 0·83 map units is non-neurovirulent for mice. Journal of General Virology 70:705–716
    [Google Scholar]
23. Wagner E. K. 1985; Individual HSV transcripts: characterization of specific genes. In The Herpesviruses 345–104 Roizman B. New York & London: Plenum Press;
    [Google Scholar]
24. Wagner E. K., Devi-rao G., Feldman L. T., Dobson A. T., Zhang Y., Flanagan W. M., Stevens J. G. 1988; Physical characterization of the herpes simplex virus latency-associated transcript in neurons. Journal of Virology 62:1194–1202
    [Google Scholar]