@article{mbs:/content/journal/jgv/10.1099/0022-1317-70-9-2481, author = "Scholz, Elke and Heinricy, Ursula and Flehmig*, Bertram", title = "Acid Stability of Hepatitis A Virus", journal= "Journal of General Virology", year = "1989", volume = "70", number = "9", pages = "2481-2485", doi = "https://doi.org/10.1099/0022-1317-70-9-2481", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-9-2481", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "acid stability", keywords = "enteroviruses", keywords = "hepatitis A virus", abstract = "Summary The acid stability of unpurified and highly purified hepatitis A virus (HAV) was tested andcompared with that of poliovirus type 1, coxsackievirus types A9 and B1 and echovirus type 9. Only HAV had a high residual infectivity after 2 h of exposure to pH 1 at room temperature, remaining infectious for up to 5 h. At 38°C, pH 1, HAV remained infectious for 90 min. Highly purified HAV was found to be infectious for 8 h at pH 1 and room temperature. This indicates that the increased stability is not due to protection by cellular material attached to the virus,but is a virus-specific marker. Under the same conditions, at pH 1 and room temperature, unpurified and highly purified HAV antigens were traceable for 5 and 4 h respectively.", }