1887

Abstract

Summary

The clinical and serological outcome of genital herpes simplex virus type 2 (HSV-2) inoculation in animals previously orally infected with HSV type 1 was evaluated. A prior HSV-1 oral infection modified the genital HSV-2 infection so that only four of 18 (22%) animals were initially symptomatic although all but one animal shed HSV-2 from the cervicovaginal area for at least 5 days following inoculation. Three of four animals with symptomatic initial disease also developed recurrences, as did an additional six animals that did not manifest acute genital disease. Anti-glycoprotein gG-1 antibody was found in 17 of 18 animals with only an HSV-1 infection and anti-gG-2 antibody in all of nine animals with only an HSV-2 infection. Anti-gG-2 antibody was detected in eight of 17 animals with a prior HSV-1 infection following HSV-2 inoculation and one had an indeterminate response. Eight of these nine animals developed recurrent genital disease compared to one of eight that did not respond to gG-2 ( < 0·006). Thus a prior oral HSV-1 infection modified both the initial presentation of HSV-2 infection and the HSV type-specific serological response.

Keyword(s): genital disease , HSV and immune response
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/content/journal/jgv/10.1099/0022-1317-70-9-2365
1989-09-01
2024-03-29
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References

  1. Ashley R. L., Militoni J., Lee F., Nahmias A., Corey L. 1988; Comparison of Western blot (immunoblot) and glycoprotein G-specific immunoblot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. Journal of Clinical Microbiology 26:662–667
    [Google Scholar]
  2. Bernstein D . I., Lovett M., Bryson Y. J. 1984; Serologic analysis of first episode non-primary genital HSV infection: presence of HSV-2 antibody in acute sera. American Journal of Medicine 77:1055–1060
    [Google Scholar]
  3. Bernstein D. I., Bryson Y. J., Lovett M. A. 1985; Antibody response to type-common and type-unique epitopes of herpes simplex virus polypeptides. Journal of Medical Virology 15:251–263
    [Google Scholar]
  4. Bernstein D. I., Stanberry L. R., Harrison C. J., Kappes J. C., Myers M. G. 1986; Antibody response, recurrence patterns and subsequent herpes simplex virus type 2 (HSV-2) re-infection following initial HSV-2 infection of guinea-pigs: effects of acyclovir. Journal of General Virology 67:1601–1612
    [Google Scholar]
  5. Bryson Y. J., Dillon M., Lovett M., Acuna G., Taylor S., Cherry J. D., Johnson B. L., Wiesmeier E., Growdon w., Creagh-kirk t., Keeney R. 1983; Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. New England Journal of Medicine 308:916–921
    [Google Scholar]
  6. Corey L., Adams H. G., Brown Z. A., Holmes K. K. 1983; Genital herpes simplex virus infections: clinical manifestations, course and complications. Annals of Internal Medicine 98:958–972
    [Google Scholar]
  7. Eberle R., Courtney R. J. 1981; Assay of type-specific and type-common antibodies to herpes simplex virus types 1 and 2 in human sera. Infection and Immunity 31:1062–1070
    [Google Scholar]
  8. Kern E. R., Glasgow l. A., Overall J. C., , Reno J. M., Boezi A. 1978; Treatment of experimental herpesvirus infection with phosphonoformate and some comparisons with phosphonacetates. Antimicrobial Agents and Chemotherapy 14:817–823
    [Google Scholar]
  9. Lee F. K., Coleman M., Pereira L., Bailey P. D., Tatsuno M., Nahmias A. J. 1985; Detection of herpes simplex virus type 2 specific antibody with glycoprotein G. Journal of Clinical Microbiology 22:641–644
    [Google Scholar]
  10. Lee F. K., Pereira L., griffin C., Reid E., Nahmias A. 1986; A novel glycoprotein for detection of herpes simplex virus type 1 specific antibodies. Journal of Virological Methods 14:111–118
    [Google Scholar]
  11. Mcclung H., Pralee S., Rawls W. E. 1976; Relative concentration in human sera of antibodies to cross-reaction and specific antigens of herpes simplex virus types 1 and 2. American Journal of Epidemiology 104:192–201
    [Google Scholar]
  12. Mertz G. J., Schmidt O., Jourden J. L., Guinan M. E., Remington M. L., FAHNLANDER A., Winter C., Holmes K. K., Corey L. 1985; Frequency of acquisition of first episode genital herpes simplex virus from symptomatic and asymptomatic source contacts. Sexually Transmitted Diseases 12:33–39
    [Google Scholar]
  13. Mertz G. J., Coombs R. W., Ashley R., Jourden J., Remington M., Winter C., Fahnlander A., Guinan M., Ducey H., Corey L. 1988; Transmission of genital herpes in couples with one symptomatic and one asymptomatic partner: a prospective study. Journal of Infectious Diseases 157:1169–1177
    [Google Scholar]
  14. Nahmias A. J., Josey W. E., Naib Z. M., Luce C. F., Duffey C. 1970; Antibodies to herpes virus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections. American Journal of Epidemiology 91:539–546
    [Google Scholar]
  15. Nahmias A. J., Dannenbarger J., Wickliffe C., Muther J. 1981; Clinical aspects of infection with herpes simplex viruses 1 and 2. In The Human Herpesviruses: An Interdisciplinary Perspective3–9 Nahmias A. J. New York: Elsevier;
    [Google Scholar]
  16. Plummer G. 1973; A review of the identification and titration of antibodies to herpes simplex viruses type 1 and 2 in human sera. Cancer Research 33:1469–1476
    [Google Scholar]
  17. Prober C. G., Hensleigh P. A., Boucher F. D., Yasakawa L. I., Au D. S., Arvin A. M. 1988; Use of routine viral cultures at delivery to identify neonates exposed to herpes simplex virus. New England Journal of Medicine 318:887–891
    [Google Scholar]
  18. Reeves W. C., Corey L., Adams H. G., Vontver L. A., Holmes K. K. 1981; Risk of recurrence after first episodes of genital herpes. New England Journal of Medicine 305:325–319
    [Google Scholar]
  19. Rooney J. F., Felser J. M., Ostrove J. M., Straus S. E. 1986; Acquisition of genital herpes from an asymptomatic sexual partner. New England Journal of Medicine 314:1561–1564
    [Google Scholar]
  20. Spear P. G. 1975; Glycoproteins specified by herpes simplex virus type 1: their synthesis, processing and antigenic relatedness to HSV-2 glycoproteins. IARC Science Publications 14:49–61
    [Google Scholar]
  21. Stanberry L. R., Kern E. R., Richards J. T., Abbott T. M., overall J. C. JR 1982; Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent diseases. Journal of Infectious Diseases 146:397–404
    [Google Scholar]
  22. Straus S. E., Rooney J. F., Sever J. L., Seidlin M., Nusinoff-lehrman S., Cremer K. 1985; Herpes simplex virus infection: biology, treatment and prevention. Annals of Internal Medicine 103:404–419
    [Google Scholar]
  23. Sullender W. M., Yasukawa L. L., Schwartz R., Pereira L., Hensleigh P. A., Prober C. G., Arvin A. M. 1988; Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery and infants with neonatal herpes. Journal of Infectious Diseases 157:164–171
    [Google Scholar]
  24. Whitley R. J. 1985; Epidemiology of herpes simplex viruses. In The Herpesviruses 31–44 Roizman B. New York: Plenum Press;
    [Google Scholar]
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