RT Journal Article SR Electronic(1) A1 Grief, Christopher A1 Hockley, D. J. A1 Fromholc, C. E. A1 Kitchin, P. A.YR 1989 T1 The Morphology of Simian Immunodeficiency Virus as Shown by Negative Staining Electron Microscopy JF Journal of General Virology, VO 70 IS 8 SP 2215 OP 2219 DO https://doi.org/10.1099/0022-1317-70-8-2215 PB Microbiology Society, SN 1465-2099, AB SUMMARY Negative staining electron microscopy was used to study sucrose gradient-purified preparations of the simian immunodeficiency virus (SIVmac251). Both isolated and aggregated virus particles were observed together with some free-lying virus cores. The cores were 110 nm long and 25 to 50 nm wide and were mainly conical or wedge-like in shape. Surface projections were seen on the envelope membrane of many of the virus particles; the knobs were approximately 6 nm in length, 10 nm wide and from an end-on view they had a Y or triangular-shaped morphology., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-8-2215