1887

Abstract

SUMMARY

The purpose of this study was to determine whether infectious herpes simplex virus type L (HSV-1) has tumorigenic properties and, if so, whether inhibition of the cytolytic replicative cycle of the virus after infection enhances tumour development. Eighty mice were subjected to repeated inoculation of HSV-1 on their upper lips after scarification, and systemic administration of acyclovir (ACV). 12--tetradecanoylphorbol 13-acetate (TPA) was used as the tumour promoter. The tumour incidence was compared to control groups each of 40 mice that were either not treated with ACV, not treated with TPA, not infected with HSV or only scarified. In the virus-infected group treated with ACV and TPA, 25% of the animals developed tumours. In the HSV-infected group treated with TPA only, 25% of the animals also developed tumours. The uninfected animals which were not treated with TPA developed tumours to a significantly lesser degree. In conclusion, the combined effects of HSV-1 and TPA, with or without ACV treatment, resulted in a significant increase in the number of tumours in comparison to the control groups.

Keyword(s): acyclovir , HSV-1 and tumour formation
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-70-7-1773
1989-07-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/70/7/JV0700071773.html?itemId=/content/journal/jgv/10.1099/0022-1317-70-7-1773&mimeType=html&fmt=ahah

References

  1. Burns J. C., Murray B. K. 1981; Conversion of herpetic lesions to malignancy by ultraviolet exposure and promoter application. Journal of Gereral Virology 55:305–313
    [Google Scholar]
  2. Hirsch J.-M., Johansson S. L., Vahlne A. 1984a; Effect of snuffand herpes simplex virus 1 on rat oral mucosa. Possible association with development of squamous cell carcinoma. Journal of Oral Pathology 13:52–62
    [Google Scholar]
  3. Hirsch J.-M., Svennerholm B., Vahlne A. 1984b; Inhibition of herpes simplex virus replication by tobacco extracts. Cancer Research 44:1991–1997
    [Google Scholar]
  4. Park N.-H., Herbosa E. G., Shklar G. 1985; Experimental development of herpes simplex virus infection in hamster buccal pouch. Oral Pathology 59:159–166
    [Google Scholar]
  5. Rapp F. 1980; Transformation by herpes simplex viruses. In Viruses in Naturally Occurring Cancers63–68 Essex M., Todaro G., Zur Hausen H. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  6. Shillitoe E. J., Silverman S. 1979; Oral cancer and herpes simplex virus - a review. Oral Surgery 48:216–224
    [Google Scholar]
  7. Svennerholm B., Olofsson S., Jeansson S., Vahlne A., Lycke E. 1984; Herpes simplex virus type-selective-enzyme linked immunosorbent assay with Helix pomatia-lectin purified antigenes. Journal of Clinical Microbiology 19:235–239
    [Google Scholar]
  8. Tucker W. E. 1982; Preclinical toxicology profile of acyclovir: an overview. American Journal of Medicine 73:27–30
    [Google Scholar]
  9. Vahlne A., Nilheden E., Svennerholm B. 1981; Multiplicity activation of herpes simplex virus in mouse neuroblastoma (C1300) cells. Archives of Virology 70:345–356
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-70-7-1773
Loading
/content/journal/jgv/10.1099/0022-1317-70-7-1773
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error