1887

Abstract

SUMMARY

We have investigated the influence of anti-rabies vaccination on the onset of the disease as well as the delay of death in foxes previously infected with rabies virus. A live vaccinia recombinant virus expressing the rabies virus glycoprotein (VVTGgRAB) was used as vaccine. Foxes were divided into six experimental groups of four animals. On day 0, each fox was experimentally infected with a rabies virus suspension. VVTGgRAB was administered by the oral route to each animal of three groups on day 0, 3 or 14. Foxes of other groups were used as unvaccinated controls or received, on day 0, the parental Copenhagen strain of vaccinia virus. The length of post-challenge survival and duration of clinical disease were recorded for each animal tested. All foxes, vaccinated or not, died from rabies as confirmed by fluorescent antibody tests. Animals vaccinated on days 0 and 3 died after a shorter period of incubation than unvaccinated controls. On the other hand, animals vaccinated on day 14 post-challenge died later than control animals. Foxes administered vaccinia virus died at the same time as unvaccinated controls. These results demonstrate that early and late death phenomena, as consequences of interactions between oral vaccination with VVTGgRAB and rabies infection, can occur in foxes.

Keyword(s): fox , rabies and vaccinia virus
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/content/journal/jgv/10.1099/0022-1317-70-6-1601
1989-06-01
2021-10-17
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References

  1. Andral L., Andral B., Blancou J. 1981; Study of the mechanisms of early death occurring after vaccination in mice inoculated with street rabies virus.. Annales de Virologie 132E:503–517
    [Google Scholar]
  2. Bijlenga G., Ganeshwaran A., Joubert L., Lery L. 1988; Le phénomène de mort précoce et stimulée chez la souris infectée puis vaccinée contre la rage.. Annales de Recherches Vétérinaires 19:135–140
    [Google Scholar]
  3. Blancou J., Aubert M. F. A., Andral L., Artois M. 1979a; Rage expérimentale du renard roux (Vulpes vulpes, L.). I. Sensibilité selon la voie d’infection et la dose infectante.. Revue de Médecine Vétérinaire 130:1001–1015
    [Google Scholar]
  4. Blancou J., Andral B., Andral L. 1979b; Cinétique des réactions à l’infection expérimentale de la souris vaccinée ou non contre la rage: étude étiopathogénique.. Annales de Microbiologie 130B:485–492
    [Google Scholar]
  5. Blancou J., Andral B., Andral L. 1980; A model in mice for the study of the early death phenomenon after vaccination and challenge with rabies virus.. Journal of General Virology 50:433–435
    [Google Scholar]
  6. Blancou J., Kieny M. P., Lathe R., Lecocq J. P., Pastoret P.-P., Soulebot J. P., Desmettre P. 1986; Oral vaccination of the fox against rabies using a live recombinant vaccinia virus.. Nature, London 322:373–375
    [Google Scholar]
  7. Blancou J., Artois M., Brochier B., Thomas L., Pastoret P.-P., Desmettre P., Languet B., Kieny M. P. 1988; Vaccination antirabique du renard, du chien et du chat par voie orale avec un recombinant du virus de la vaccine et de la rage.. Annales de Recherches Vétérinaires (in press)
    [Google Scholar]
  8. Brochier B., Thomas I., Iokem A., Ginter A., Kalpers J., Paquot A., Costy F., Pastoret P.-P. 1988a; A field trial in Belgium to control fox rabies by oral immunization.. Veterinary Record 123:618–621
    [Google Scholar]
  9. Brochier B., Languet B., Blancou J., Kieny M. P., Lecocq J. P., Costy F., Desmettre P., Pastoret P.-P. 1988b; Use of recombinant vaccinia-rabies virus for oral vaccination of fox cubs (Vulpes vulpes, L.) against rabies.. Veterinary Microbiology 18:103–108
    [Google Scholar]
  10. Brochier B., Languet B., Blancou J., Thomas I., Kieny M. P., Lecocq J. P., Desmettre P., Pastoret P.-P. 1988c; Innocuité du virus recombinant vaccine-rage chez quelques espèces non-cibles.. In Agriculture - Vaccination to Control Rabies in Foxes118–123 Luxembourg: Commission of the European Communities; EUR 11439
    [Google Scholar]
  11. Dubreuil M., Andral L., Aubert M., Blancou J. 1979; The oral vaccination of foxes against rabies. An experimental study.. Annales de Recherches Vétérinaires 10:9–21
    [Google Scholar]
  12. Kieny M. P., Lathe R., Drillien R., Spehner D., Skory S., Schmitt D., Wiktor T., Koprowski H., Lecocq J. P. 1984; Expression of rabies virus glycoprotein from a recombinant virus.. Nature, London 312:163–166
    [Google Scholar]
  13. Koprowski H. 1973; The mouse inoculation test.. In Laboratory Techniques in Rabies85–93 Kaplan M. M., Koprowski H. Geneva: World Health Organization;
    [Google Scholar]
  14. Pastoret P.-P., Frisch R., Blancou J., Brochier B., Wolff F., Roboly O., Schneider L. G. 1987; Campagne internationale de vaccination antirabique du renard par voie orale menée au grand-duché de Luxembourg, en Belgique et en France.. Annales de Médecine Vétérinaire 131:441–447
    [Google Scholar]
  15. Prabhakar B. S., Nathanson N. 1981; Acute rabies death mediated by antibodies.. Nature, London 290:590
    [Google Scholar]
  16. Rupprecht C. E., Wiktor T., Johnston D. H., Hamir A. N., Dietzschold B., Wunner W. H., Glickman L. T., Koprowski H. 1986; Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.. Proceedings of the National Academy of Sciences, U.S.A. 83:7947–7950
    [Google Scholar]
  17. Schneider L. G., Cox J. H. 1983; Ein Feldversuch zur oralen Immunisierung von Füchsen gegen die Tollwut in der Bundesrepublik Deutschland.. Tierärztliche Umschau 38:315–324
    [Google Scholar]
  18. Sikes R. K., Cleary W. F., Koprowski H., Wiktor T. J., Kaplan M. M. 1971; Effective protection of monkeys against death from street virus by post-exposure administration of tissue-culture rabies vaccine.. Bulletin of the World Health Organization 45:1–11
    [Google Scholar]
  19. Steck F., Wandeler A., Bichsel P., Capt S., Schneider L. 1982; Oral immunisation of foxes against rabies. A field study.. Zentralblatt für Veterinärmedizin 29:372–396
    [Google Scholar]
  20. Thiriart C., Iokem A., Costy F., Schwers A., Brochier B., De Meurichy M., Peharpre D., Pastoret P.-P. 1985; Immunization of young foxes against rabies: interaction between vaccination and natural infection.. Annales de Recherches Vétérinaires 16:289–292
    [Google Scholar]
  21. Tolson N. D., Charlton K. M., Stewart R. B., Cambell J. B., Wiktor T. J. 1987; Immune response in skunks to a vaccinia virus recombinant expressing the rabies virus glycoprotein.. Canadian Journal of Veterinary Research 51:363–366
    [Google Scholar]
  22. Wiktor T. J., Macfarlan R. I., Dietzschold B., Rupprecht C., Wunner W. J. 1985; Immunogenic properties of vaccinia recombinant virus expressing the rabies glycoprotein.. Annales de l’institut Pasteur/Virologie 136E:405–411
    [Google Scholar]
  23. Zar J. H. 1974 Biostatistical Analysis. Englewood Cliffs: Prentice-Hall;
    [Google Scholar]
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