1887

Abstract

SUMMARY

Host genetic control of the incubation period of Creutzfeldt-Jakob disease (CJD) was studied using various inbred strains of mice, including B10 congenic strains. Various incubation periods were found in mice injected either intracerebrally or intraperitoneally with the Fukuoka 1 strain of the CJD agent; NZW/Sea and A/JJms had the shortest, and B10.AKM/Ola and C57BL/6J the longest, incubation periods. Length of the CJD incubation period did not correlate with the genetic markers tested, i.c. the murine major histocompatibility (H-2) complex (which has previously been reported to be linked to a gene influencing CJD incubation period in mice), coat colour or sex genes. In NZW/Sea × C57BL/6J F hybrid mice the CJD incubation periods were similar to that of the parent with the longest incubation period. Incubation periods of the backcross progeny from F and NZW/Sea were intermediate between those of the parental mice and had a unimodal distribution pattern. A similar observation was made on the progeny of the A/JJms × C57BL/6J mating. On the other hand, the length of incubation period for the NZW/Sea × B10.AKM/Ola F hybrid fell between those for the two parents and the NZW/Sea × A/JJms F hybrid had a significantly longer incubation period than those of the two parents. These results suggest that polygenes probably control the length of the CJD incubation period in mice.

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1989-06-01
2022-09-28
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References

  1. Asher D. M., Masters C. L., Gajdusek D. C., Gibbs C. J. JR 1983; Familial spongiform encephalopathies.. In Genetics of Neurological and Psychiatric Disorders273–291 Kety S. S., Rowland L. P., Sidman R. L., Matthysse S. M. New York: Raven Press;
    [Google Scholar]
  2. Bruce M. E., Dickinson A. G. 1979; Biological stability of different classes of scrapie agent.. In Slow Transmissible Diseases of the Nervous System 271–86 Prusiner S. B., Hadlow W. J. New York & London: Academic Press;
    [Google Scholar]
  3. Bruce M. E., Dickinson A. G. 1985; Genetic control of amyloid plaque production and incubation period in scrapie-infected mice.. Journal of Neuropathology and Experimental Neurology 44:285–294
    [Google Scholar]
  4. Bruce M. E., Dickinson A. G. 1987; Biological evidence that scrapie agent has an independent genome.. Journal of General Virology 68:79–89
    [Google Scholar]
  5. Cartson G. A., Kingsbury D. T., Goodman P. A., Coleman S., Marshall S. T., Dearmond S., Westaway D., Prusiner S. B. 1986; Linkage of prion protein and scrapie incubation time genes.. Cell 46:503–511
    [Google Scholar]
  6. Carp R. I., Moretz R. C., Natelli M., Dickinson A. G. 1987; Genetic control of scrapie: incubation period and plaque formation in I mice.. Journal of General Virology 68:401–407
    [Google Scholar]
  7. Dickinson A. G. 1975; Host-pathogen interactions in scrapie.. Genetics 79: supplement 387–395
    [Google Scholar]
  8. Dickinson A. G., Fraser H. 1977; Scrapie: pathogenesis in inbred mice: an assessment of host control and response involving many strains of agent.. In Slow Virus Infections of the Central Nervous System1–14 ter Meulen V., Katz M. New York: Springer;
    [Google Scholar]
  9. Dickinson A. G., Meikle V. M. H. 1971; Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent.. Molecular and General Genetics 112:73–79
    [Google Scholar]
  10. Dickinson A. G., Outram G. W. 1979; The scrapie replication-site hypothesis and its implications for pathogenesis.. In Slow Transmissible Diseases of the Nervous System 213–31 Prusiner S. B., Hadlow W. J. New York & London : Academic Press;
    [Google Scholar]
  11. Dickinson A. G., Meikle V. M. H., Fraser H. 1968; Identification of a gene which controls the incubation period of some strains of scrapie agent in mice.. Journal of Comparative Pathology 78:293–299
    [Google Scholar]
  12. Gajdusek D. C. 1977; Unconventional viruses and the origin and disappearance of kuru.. Science 197:943–960
    [Google Scholar]
  13. Hunter N., Hope J., Mcconnell I., Dickinson A. G. 1987; Linkage of the scrapie-associated fibril protein (PrP) gene and Sinc using congenic mice and restriction fragment length polymorphism analysis.. Journal of General Virology 68:2711–2716
    [Google Scholar]
  14. Kärber G. 1931; Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche.. Arthiv für Experimentelle Pathologie und Pharmakologie 162:480–483
    [Google Scholar]
  15. Kimberlin R. H., Cole S., Walkbr C. A. 1987; Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters.. Journal of General Virology 68:1875–1881
    [Google Scholar]
  16. Kingsbury D. T., Kasper K. C., Stites D. P., Watson J. D., Hogan R. N., Prusiner S. B. 1983; Genetic control of scrapie and Creutzfeldt-Jakob disease in mice.. Journal of Immunology 131:491–496
    [Google Scholar]
  17. Kuroda Y., Kaneoka H., Shibasaki H., Yamaguchi M. 1985; HLA typing of Japanese patients with Creutzfeldt-Jakob disease: significant association with HLA-DQw3.. New England Journal of Medicine 312:1128
    [Google Scholar]
  18. Manuelidis E. E., Gorgacz E. J., Manuelidis L. 1978; Transmission of Creutzfeldt-Jakob disease with scrapie-like syndromes to mice.. Nature, London 271:778–779
    [Google Scholar]
  19. Masters C. L., Gajdusek D. C., Gibbs C. J. JR 1981; The familial occurrence of Creutzfeldt-Jakob disease.. Brain 104:535–558
    [Google Scholar]
  20. Mohri S., Handa S., Tateishi J. 1987; Lack of effect of thymus and spleen on the incubation period of Creutzfeldt-Jakob disease in mice.. Journal of General Virology 68:1187–1189
    [Google Scholar]
  21. Outram G. W. 1976; The pathogenesis of scrapie in mice.. In Slow Virus Diseases of Animals and Man325–357 Kimberlin R. H. Amsterdam; North-Holland:
    [Google Scholar]
  22. Prusiner S. B. 1982; Novel proteinaceous infectious particles cause scrapie.. Science 216:136–144
    [Google Scholar]
  23. Sparkes R. S., Simon M., Cohn V. H., Fournier R. E. K., Lem J., Klisak I., Heinzmann C., Blatt C., Lucero M., Mohandas T., Dearmond S. J., Westaway D., Prusiner S. B., Weiner L. P. 1986; Assignment of the human and mouse prion protein genes to homologous chromosomes.. Genetics 83:7358–7362
    [Google Scholar]
  24. Tateishi J., Ohta M., Koga M., Satoh Y., Kuroiwa Y. 1979; Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents.. Annals of Neurology 5:581–584
    [Google Scholar]
  25. Tateishi J., Sato Y., Koga M., Doi H., Ohta M. 1980; Experimental transmission of human subacute spongiform encephalopathy to small rodents.. Acta neuropathologica 51:127–134
    [Google Scholar]
  26. Tateishi J., Hikita K., Kitamoto T., Nagara H. 1987; Experimental Creutzfeldt-Jakob disease: introduction of amyloid plaques in rodents.. In Prions415–426 Prusiner S. B., McKinley M. P. San Diego: Academic Press;
    [Google Scholar]
  27. Westaway D., Goodman P. A., Mirenda C. A., McKinley M. P., Carlson G. A., Prusiner S. B. 1987; Distinct prion proteins in short and long scrapie incubation period mice.. Cell 51:651–662
    [Google Scholar]
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