@article{mbs:/content/journal/jgv/10.1099/0022-1317-70-4-1005, author = "Tilbrook, Peta A. and Greenoak, Gavin E. and Reeve, Vivienne E. and Canfield, Paul J. and Gissmann, Lutz and Gallagher, Clifford H. and Kulski, Jerzy K.", title = "Identification of Papillomaviral DNA Sequences in Hairless Mouse Tumours Induced by Ultraviolet Irradiation", journal= "Journal of General Virology", year = "1989", volume = "70", number = "4", pages = "1005-1009", doi = "https://doi.org/10.1099/0022-1317-70-4-1005", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-4-1005", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "papillomavirus", keywords = "cancer", keywords = "hairless mouse", abstract = "SUMMARY Papillomas, carcinomas in situ and squamous cell carcinomas were induced using ultraviolet irradiation in the hairless mouse strain Mus musculus HRA/Skh. DNA extracted from biopsies was examined using Mastomys natalensis papillomaviral DNA as a hybridization probe at reduced stringency. Sequences homologous to the probe were detected in 16 of 24 papillomas, five of five carcinomas in situ and six of 38 squamous cell carcinomas. A number of tumour DNAs (16/33) also hybridized with mixed DNAs of human papillomavirus types 11, 13, 16 and 18 at reduced stringency. This suggests a role for the hairless mouse as a laboratory model for the study of the involvement of papillomaviruses in malignant transformations.", }