%0 Journal Article %A Westenbrink, F. %A Kimman, T. G. %A Brinkhof, J. M. A. %T Analysis of the Antibody Response to Bovine Respiratory Syncytial Virus Proteins in Calves %D 1989 %J Journal of General Virology, %V 70 %N 3 %P 591-601 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-70-3-591 %K antibody response %K RIA %K bovine %K RSV %I Microbiology Society, %X SUMMARY The antibody response in calves to natural infections with bovine respiratory syncytial virus (BRSV) was analysed by radioimmunoprecipitation assays. Antibodies to virus proteins of M r 200K (L), 87K (G), 46K (F1), 41K (N), 35K (P), 28K and 24K (F2), 27K (M), 22K and < 14K could be identified. Recovery of 6- to 7-month-old calves from severe BRSV-associated disease was accompanied by the development of an antibody response to the virus, which was directed mainly to the F and N proteins. Calves of 2 to 3 weeks of age possessed moderate levels of maternal antibodies to BRSV particularly directed to the F and N proteins but became seriously ill after infection. The antibody response in these calves was severely suppressed. In the sera of 4- to 9-month-old calves that died in the course of infection, high antibody levels to the virus were found, which were directed at least to the F and N proteins. The presence or development of antibodies to the F and N proteins appears insufficient for protection against or recovery from BRSV infections. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-3-591