1887

Abstract

SUMMARY

Infection of chickens by a virulent avian influenza A virus, A/turkey/Ont/7732/66 (H5N9), was associated with a severe lymphopenia. High titres of infectious virus were found in lymphoid tissues early in infection and were accompanied by severe damage to the lymphocyte populations as demonstrated by histopathological examination. Non-lymphoid cell populations in these tissues were unaffected, as were other organs examined. The viral nucleoprotein was localized by immunoperoxidase staining to lymphocytes in affected tissues early in infection.

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/content/journal/jgv/10.1099/0022-1317-70-2-467
1989-02-01
2024-12-14
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References

  1. Acland H. M., Silverman Bachin L. A., Eckroade R. J. 1984; Lesions in broiler and layer chickens in an outbreak of highly pathogenic avian influenza virus infection.. Veterinary Pathology 21:564–569
    [Google Scholar]
  2. Bosch F. X., Orlich M., Klenk H.-D., Ron R. 1979; The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses.. Virology 95:197–207
    [Google Scholar]
  3. Gross W. B., Siegel H. S. 1984; Evaluation of the heterophil/lymphocyte ratio as a measure of stress in chickens.. Avian Diseases 27:972–979
    [Google Scholar]
  4. Hinshaw V. S., Webster R. G., Turner B. 1978; Novel influenza A viruses isolated from Canadian feral ducks : including strains antigenically related to swine influenza (HswlN1) viruses.. Journal of General Virology 41:115–127
    [Google Scholar]
  5. Kawaoka Y., Naweve C. W., Webster R. G. 1984; Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?. Virology 139:303–316
    [Google Scholar]
  6. Kawaoka Y., Nestorowicz A., Alexander D. J., Webster R. G. 1987; Molecular analysis of the hemagglutinin genes of H5 influenza viruses: origin of a virulent turkey strain.. Virology 158:218–227
    [Google Scholar]
  7. Lang G., Narayan O., Rouse B. T., Ferguson A. E., Connell M. C. 1968; A new influenza A virus infection in turkeys. II. A highly pathogenic variant, A/turkey/Ontario/7732/66.. Canadian Veterinary Journal 9:151–160
    [Google Scholar]
  8. Narayan O., Thorse J., Hulland T. J., Ankeli G., Joseph P. G. 1972; Pathogenesis of lethal influenza virus infection in turkeys. I. Extraneural phase of infection.. Journal of Comparative Pathology 82:129–137
    [Google Scholar]
  9. Van Wyke K. L., Hinshaw V. S., Bean W. J., Webster R. G. 1980; Antigenic variation of influenza A virus nucleoprotein detected with monoclonal antibodies.. Journal of Virology 35:24–30
    [Google Scholar]
  10. Zinkl J. G. 1986; Avian hematology.. In Schalm’s Veterinary Hematology, 4.256–273 Jain N. C. Philadelphia: Lea & Febiger;
    [Google Scholar]
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