1887

Abstract

SUMMARY

Infection of L-A9 cells with Marituba virus produces a severe inhibition of protein synthesis. This inhibition is temporally correlated with an increase in the intracellular Na concentration and a decrease in the intracellular K concentration. However in Marituba virus-infected cells the intracellular level of Na and K ions and protein synthesis remained unaltered. Incubation of both cell types at high NaCl concentration facilitated the translation of viral RNA whereas the cellular protein synthesis was inhibited. Using a hypotonic medium, the opposite was found. Results are discussed in terms of a possible involvement of these ions in the viral translational process.

Keyword(s): cations , MTBV and protein synthesis
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/content/journal/jgv/10.1099/0022-1317-70-12-3493
1989-12-01
2022-10-02
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