Virus-specific cytotoxic T lymphocytes (CTL) mediate their antiviral activity either by direct lysis of infected cells, or by the release of soluble lymphokines, or by a combination of the two. We have examined the role played by interferon-gamma (IFN-γ) and tumour necrosis factor (TNFα) in virus clearance. the amount of IFN-γ synthesized by some lymphocytic choriomeningitis virus-specific H-2-restricted CTL clones was quantitatively too small to correlate with a direct antiviral activity . However, treatment of mice with a neutralizing monoclonal antibody to IFN-γ significantly inhibited the clearance of virus from the spleens of acutely infected mice given adoptive transfers of immune spleen cells. Additionally, mice treated with exogenous recombinant murine IFN-γ 24 h before or at the same time as virus inoculation showed reduced virus titres in their spleens. Hence, IFN-γ displayed a direct antiviral effect . In contrast, treatment of mice with recombinant TNFα had no effect on virus clearance and thus TNFα is unlikely to play a significant role in this acute viral infection.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error