1887

Abstract

SUMMARY

Using antisera made against peptides corresponding to different regions of the large subunit of herpes simplex virus type 1 ribonucleotide reductase we have probed proteolytic fragments of this protein and found that at least a part of its unique N-terminal domain is not necessary for enzyme activity. This non-essential region encompasses the domain previously predicted to be composed of sheets with a well buried core of hydrophobic residues. Truncated forms of the large subunit are generated and are located almost exclusively in the nucleus.

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1989-12-01
2021-10-19
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