1887

Abstract

SUMMARY

We have investigated whether herpes simplex virus (HSV) contains structural polypeptides which are modified by myristic acid. We demonstrate that herpes simplex virions contain a family of myristylated proteins, approximately 13000 to 16000. These were mapped, using HSV-1/HSV-2 intertypic recombinants, to 0·130 to 0·204 map units on the virus genome. Using anti-peptide sera, raised against the carboxy-terminus of the predicted UL11 gene product, we have established that the myristylated virion polypeptides are products of the viral gene UL11.

Keyword(s): gene UL11 , HSV-1 and myristylation
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1989-12-01
2022-01-23
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