RT Journal Article SR Electronic(1) A1 Scott*, Simon D. A1 Ross, Norman L. J. A1 Binns, Matthew M.YR 1989 T1 Nucleotide and Predicted Amino Acid Sequences of the Marek's Disease Virus and Turkey Herpesvirus Thymidine Kinase Genes; Comparison with Thymidine Kinase Genes of Other Herpesviruses JF Journal of General Virology, VO 70 IS 11 SP 3055 OP 3065 DO https://doi.org/10.1099/0022-1317-70-11-3055 PB Microbiology Society, SN 1465-2099, AB Summary In this paper we present the nucleotide sequences of the thymidine kinase (TK) genes of two avian herpesviruses: a highly oncogenic strain of Marek’s disease virus (MDV strain RB1B) and its serologically related vaccine virus, the herpesvirus of turkeys (HVT strain Fc-126). The predicted coding regions of the two genes are 1029 and 1050 nucleotides respectively, corresponding to polypeptides of 343 and 350 amino acids in length. Putative nucleotide- and nucleoside-binding sites have been identified within the two predicted amino acid sequences. The MDV and HVT TK amino acid sequences exhibit 58.2% amino acid identity. Comparison with other available herpesvirus TK sequences reveals a greater homology to those of the alphaherpes-viruses than to those of the gammaherpesviruses. No overall homology was found when compared with the chicken cytoplasmic TK sequence., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-11-3055