%0 Journal Article %A Weir*, Jerry P. %A Bennett, Malcolm %A Allen, Elizabeth M. %A Elkins, Karen L. %A Martin, Stephen %A Rouse, Barry T. %T Recombinant Vaccinia Virus Expressing the Herpes Simplex Virus Type 1 Glycoprotein C Protects Mice against Herpes Simplex Virus Challenge %D 1989 %J Journal of General Virology, %V 70 %N 10 %P 2587-2594 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-70-10-2587 %K vaccinia virus %K glycoprotein C %K HSV-1 %I Microbiology Society, %X Summary The gene encoding the herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) was isolated and cloned into a vaccinia virus insertion vector, and the resulting vaccinia-gC vector was used to construct a recombinant vaccinia virus that expressed gC (VVgC5). Infection of cells with VVgC5 resulted in cell surface expression of authentic HSV-1 gC. HSV-1 gC-specific neutralizing antibodies were produced in VVgC5-immunized mice, and lymphocytes exhibited an HSV-1-specific proliferation response in vitro following infection. More importantly, VVgC5-immunized mice were resistant to subsequent lethal HSV-1 challenge. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-10-2587