1887

Abstract

Summary

The gene encoding the herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) was isolated and cloned into a vaccinia virus insertion vector, and the resulting vaccinia-gC vector was used to construct a recombinant vaccinia virus that expressed gC (VVgC5). Infection of cells with VVgC5 resulted in cell surface expression of authentic HSV-1 gC. HSV-1 gC-specific neutralizing antibodies were produced in VVgC5-immunized mice, and lymphocytes exhibited an HSV-1-specific proliferation response following infection. More importantly, VVgC5-immunized mice were resistant to subsequent lethal HSV-1 challenge.

Keyword(s): glycoprotein C , HSV-1 and vaccinia virus
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/content/journal/jgv/10.1099/0022-1317-70-10-2587
1989-10-01
2022-01-22
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