1887

Abstract

SUMMARY

Vesicular stomatitis virus (VSV) establishes a non-cytopathic persistent infection in cells. The synthesis of the viral glycoprotein G was specifically inhibited during a post-transcriptional step, whereas the synthesis and turnover of its mRNA were not modified compared with the other viral mRNAs. Another viral glycoprotein, migrating slightly faster than G protein on an SDS–polyacrylamide gel, was detected in infected cells. This protein showed most of the characteristics of the intracellular Gs protein found in infected vertebrate cells. The amounts of G protein integrated into mature virions and of soluble Gs protein secreted into the culture medium were reduced greatly during VSV infection in cells.

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1989-01-01
2022-01-19
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