1887

Abstract

Summary

The sequence of the M gene of the Hu2 strain of measles virus has been determined. In the coding region of the gene, six nucleotide replacements had occurred with respect to the sequence of the M gene of the Edmonston strain. Two of these were silent and only four led to amino acid replacements in the protein sequence even though in SDS-PAGE the mobility of the protein would indicate an increase of 2000. No changes were observed in the 5′ untranslated regions of the gene. Two changes were observed in the 3′ untranslated region of the gene. The sequences are compared to those recently published for subacute sclerosing panencephalitis viruses.

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1988-09-01
2024-04-25
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References

  1. BELLINI W. J., ENGLUND G., RICHARDSON C. D., ROZENBLATT S., LAZZARINI R. A. 1986; Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences and deduced amino acid sequences. Journal of Virology 58:408–416
    [Google Scholar]
  2. CAMPBELL J. J., COSBY S. L., SCOTT J. K., RIMA B. K., MARTIN S. J., APPEL M. 1980; A comparison of measles and canine distemper virus polypeptides. Journal of General Virology 48:149–159
    [Google Scholar]
  3. CATTANEO R., SCHMID A., REBMANN G., BACZKO K., TER MEULEN V., BELLINI W. J., ROZENBLATT S., BILLETER M. A. 1986; Accumulated measles virus mutations in a case of subacute sclerosing panencephalitis; interrupted matrix protein reading frame and transcription alteration. Virology 154:97–107
    [Google Scholar]
  4. CATTANEO R., SCHMID A., BILLETER M. A., SHEPPARD R. D., UDEM S. A. 1988; Multiple viral mutations rather than host factors cause defective measles virus gene expression in a subacute sclerosing panencephalitis cell line. Journal of Virology 62:1388–1397
    [Google Scholar]
  5. GUBLER U., HOFFMAN B. J. 1983; A simple and very efficient method for generating cDNA libraries. Gene 25:263–269
    [Google Scholar]
  6. HALL W. W., LAMB R. A., CHOPPIN P. W. 1979; Measles and subacute sclerosing panencephalitis virus proteins; lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proceedings of the National Academy of Sciences, U.S.A 76:2047–2051
    [Google Scholar]
  7. MCGRATH I. P., CAPER D. J., GOEDDEL D. V., LEVINSON A. D. 1984; Comparative biochemical properties of normal and activated human ras p21 protein. Nature, London 310:644–649
    [Google Scholar]
  8. MAWHINNY H., ALLEN I., BEARE J. M., BRIDGES J. M., CONNOLLY J. H., HAIRE M., NEVIN N. C, NEILL D. W., HOBBS J. R. 1971; Dysgammaglobinaemia complicated by disseminated measles virus. British Medical Journal ii:380
    [Google Scholar]
  9. RIMA B. K., MARTIN S. J., GOULD E. A. 1979; A comparison of polypeptides in measles and SSPE virus strains. Journal of General Virology 42:603–608
    [Google Scholar]
  10. RIMA B. K., ROBERTS M. W., MARTIN S. J. 1983; Comparison of morbillivirus proteins by limited proteolysis. Medical Microbiology and Immunology 171:203–213
    [Google Scholar]
  11. RIMA B. K., BACZKO K., CLARKE D. K., CURRAN M. D., MARTIN S. J., BILLETER M. A., TER MEULEN V. 1986; Characterization of clones for the sixth (L) gene and a transcriptional map for morbilliviruses. Journal of General Virology 67:1971–1978
    [Google Scholar]
  12. SHESHBERADARAN H., CHEN S-N., NORRBY E. 1983; Monoclonal antibodies against five structural components of measles virus. I. Characterization of antigenic determinants of nine strains of measles virus. Virology 128:341–353
    [Google Scholar]
  13. WECHSLER S., FIELDS B. N. 1978; Differences between intracellular polypeptides of measles virus and subacute sclerosing panencephalitis virus. Nature, London 272:458–460
    [Google Scholar]
  14. WONG T. C, WIPF G., HIRANO A. 1987; The measles virus matrix gene and gene product defined by in vitro and in vivo expression. Virology 157:497–508
    [Google Scholar]
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