1887

Abstract

Summary

In different strains of inbred Syrian golden hamsters (), the lymphocytic choriomeningitis virus (LCMV) strains WE and Armstrong (ARM) produced systemic infection with infective virus and viral antigens detected predominantly in reticuloendothelial organs. Host and virus strain-dependent fatal wasting disease also occurred. After infection with WE, all MHA and PD4 hamsters died of a progressive wasting disease and infectivity persisted in organs at relatively high titres. LSH and CB strain hamsters resisted lethal disease and totally eliminated infection. LVG and LHC strain hamsters were intermediate in susceptibility to WE; some died of wasting and had persistently infected organs, while others cleared infection and survived. ARM was avirulent causing an inapparent infection in all hamsters. LCMV antibody responses were temporally comparable for all hamsters with either lethal or non-lethal infection. Histologically, lymphoid hyperplasia and low-grade systemic perivascular mononuclear leukocyte infiltration were found in all LCMV-infected hamsters. However, non-necrotic segmental ileal changes, which included vascular congestion, minimal haemorrhage and crypt epithelial growth extension into the intestinal wall, were found in susceptible hamsters when infected with the lethal WE strain.

Keyword(s): ileitis , LCMV and pathogenesis
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1988-09-01
2021-10-28
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References

  1. ACKERMANN R. 1973 Epidemiologic aspects of lymphocytic choriomeningitis in man. Lymphocytic Choriomeningitis Virus and Other Arenaviruses233–237 Edited by Lehmann-Grube F. Wien & New York: Springer-Verlag;
    [Google Scholar]
  2. ARMSTRONG C., LILLIE R. D. 1934; Experimental lymphocytic choriomeningitis of monkeys and mice produced by a virus encountered in studies of the 1933 St. Louis encephalitis epidemic. Public Health Reports 49:1019–1027
    [Google Scholar]
  3. BARRETT A. D. T., JOHNSON J. A., CROSS A. J., TAYLOR G. R. 1986; Neurochemical changes in brains of mice infected with Pichinde virus. Medical Microbiology and Immunology 175:213–215
    [Google Scholar]
  4. BOOTHE A. D., CHEVILLE N. F. 1967; The pathology of proliferative ileitis of the golden Syrian hamster. Pathologia veterinaria 4:31–44
    [Google Scholar]
  5. BUCHMEIER M. J., RAWLS W. E. 1977; Variation between strains of hamsters in the lethality of Pichinde virus infections. Infection and Immunity 16:413–421
    [Google Scholar]
  6. DOYLE M. V., OLDSTONE M. B. A. 1978; Interactions between viruses and lymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections. Journal of Immunology 121:1262–1269
    [Google Scholar]
  7. FÖRSTER V., WACHENDÖRFER G. 1973 Inapparent infection of Syrian hamsters with the virus of lymphocytic choriomeningitis. Lymphocytic Choriomeningitis Virus and Other Arenaviruses113–120 Edited by Lehmann-Grube F. Wien & New York: Springer-Verlag;
    [Google Scholar]
  8. GEE S. R., CHAN M. A., CLARKE D. A., RAWLS W. E. 1981; Susceptibility to fatal Pichinde virus infection in the Syrian hamster. Advances in Experimental Medicine and Biology 134:327–338
    [Google Scholar]
  9. GENOVESI E. V., PETERS C J. 1987a; Susceptibility of inbred Syrian golden hamsters (Mesocricetus auratus) to lethal disease by lymphocytic choriomeningitis virus. Proceedings of the Society for Experimental Biology and Medicine 185:250–261
    [Google Scholar]
  10. GENOVESI E. V., PETERS C. J. 1987b; Immunosuppression-induced susceptibility of inbred hamsters to lethal disease by lymphocytic choriomeningitis virus infection. Archives of Virology 97:61–76
    [Google Scholar]
  11. JACOBY R. O., JOHNSON E. A. 1981; Transmissible ileal hyperplasia. Advances in Experimental Medicine and Biology 134:267–290
    [Google Scholar]
  12. JAHRLING P. B., EDDY G. A. 1980 Arenaviruses. Manual of Clinical Immunology, 2nd edn.667–671 Edited by Rose N. R., Friedman H. Washington, D.C.: American Society for Microbiology;
    [Google Scholar]
  13. JAHRLING P. B., HESSE R. A., EDDY G. A., JOHNSON K. M., CALLIS R. T., STEPHEN E. L. 1980; Lassa virus infection in rhesus monkeys: pathogenesis and treatment with ribavirin. Journal of Infectious Diseases 141:580–589
    [Google Scholar]
  14. JAHRLING P. B., HESSE R. A., RHODERICK J. B., ELWELL M. A., MOE J. B. 1981; Pathogenesis of a Pichinde virus strain adapted to produce lethal infections in guinea pigs. Infection and Immunity 32:872–880
    [Google Scholar]
  15. JAHRLING P. B., SMITH S., HESSE R. A., RHODERICK J. B. 1982; Pathogenesis of Lassa virus infection in guinea pigs. Infection and Immunity 37:771–778
    [Google Scholar]
  16. KLAVINSKIS L. S., OLDSTONE M. B. A. 1986; Perturbation of endocrine functions during persistent infection of mice with lymphocytic choriomeningitis virus. Medical Microbiology and Immunology 175:117–119
    [Google Scholar]
  17. KENYON R. H., GREEN D. E., PETERS C. J. 1985; Effect of immunosuppression on experimental Argentine hemorrhagic fever in guinea pigs. Journal of Virology 53:75–80
    [Google Scholar]
  18. LEHMANN-GRUBE F., POPESCU M., SCHAEFER H., GSCHWENDER H. H. 1975; LCM virus infection of cells in vitro. Bulletin of the World Health Organization 52:443–456
    [Google Scholar]
  19. MIMS C. A., SUBRAHMANYAN T. P. 1966; Immunofluorescence study of the mechanism of resistance to superinfection in mice carrying the lymphocytic choriomeningitis virus. Journal of Pathology and Bacteriology 91:403–415
    [Google Scholar]
  20. MURPHY F. A., WINN W. C, WALKER D. H., FLEMISTER M. R., WHITFIELD S. G. 1976; Early lymphoreticular viral tropism and antigen persistence: Tamiami virus infection in the cotton rat. Laboratory Investigation 34:125–140
    [Google Scholar]
  21. NELLES M. J., STREILEIN J. W. 1980; Immune response to acute virus infection in the Syrian hamster. I. Studies on genetic restrictions of cell-mediated cytotoxicity. Immunogenetics 10:185–199
    [Google Scholar]
  22. OLDSTONE M. B. A., HOLMSTOEN J., WELSH R. M. 1977; Alterations in acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus. Journal of Cellular Physiology 91:469–472
    [Google Scholar]
  23. PARKER J. C, IGEL H. J., REYNOLDS R. K., LEWIS A. M., ROWE W. P. 1976; Lymphocytic choriomeningitis virus infection in fetal, newborn, and young adult Syrian hamsters (Mesocricetus auratus). Infection and Immunity 13:967–981
    [Google Scholar]
  24. PETERS C. J. 1984 Arenaviruses. Textbook of Human Virology513–545 Edited by Belshe R. Littleton: PSB Publishing Company;
    [Google Scholar]
  25. PETERS C. J., JOHNSON K. M. 1984 Hemorrhagic fever viruses: evolving concepts in viral pathogenesis illustrated by selected diseases in humans. Concepts in Viral Pathogenesis325–337 Edited by Notkins A. L., Oldstone M. B. A. Wien & New York: Springer-Verlag;
    [Google Scholar]
  26. PETERS C. J., JÄHRLING P. B., LIU C. T., KENYON R. H., MCKEE K. T. JR, BARRERA-ORO J. G. 1987; Experimental studies of arenaviral hemorrhagic fevers. Current Topics in Microbiology and Immunology 134:5–68
    [Google Scholar]
  27. POPESCU M., OSTROW D. H. 1982; Multiplication of lymphocytic choriomeningitis virus in thymocytes during its persistence in mice. Journal of General Virology 61:293–298
    [Google Scholar]
  28. RHODES A. J., CHAPMAN M. 1950; Further observations on interference between lymphocytic choriomeningitis and MM viruses. Canadian Journal of Research E28:245–255
    [Google Scholar]
  29. RIVERS T. M., SEOIR T. F. M. 1936; Meningitis in man caused by a filtrable virus. II. Identification of the etiological agent. Journal of Experimental Medicine 63:415–432
    [Google Scholar]
  30. RIVIERE Y., AHMED R., SOUTHERN P. J., BUCHMEIER M. J., OLDSTONE M. B. A. 1985; Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment. Journal of Virology 55:704–709
    [Google Scholar]
  31. SCHWARTZ R., LÖHLER J., LEHMANN-GRUBE F. 1978; Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus. Journal of General Virology 39:565–570
    [Google Scholar]
  32. SKINNER H. H., KNIGHT E. H. 1979; The potential role of Syrian hamsters and other small animals as reservoirs of lymphocytic choriomeningitis virus. Journal of Small Animal Practice 20:145–161
    [Google Scholar]
  33. SMADEL J. E., WALL M. J. 1942; Lymphocytic choriomeningitis in the Syrian hamster. Journal of Experimental Medicine 75:581–591
    [Google Scholar]
  34. THACKER W. L., LEWIS V. J., SHADDOCK J. H., WINKLER W. G. 1982; Infection of Syrian hamsters with lymphocytic choriomeningitis virus: comparison of detection methods. American Journal of Veterinary Research 43:1500–1502
    [Google Scholar]
  35. VOLKERT M., HANNOVER LARSEN J. 1965; Studies on immunological tolerance to LCM virus. 5. The induction of tolerance to the virus. Acta pathologica et microbiologica scandinavica 63:161–171
    [Google Scholar]
  36. WALKER D. H., WULFF H., LANGE J. V., MURPHY F. A. 1975a; Comparative pathology of Lassa virus infection in monkeys, guinea pigs, and Mastomys natalensis. Bulletin of the World Health Organization 52:523–534
    [Google Scholar]
  37. WALKER D. H., WULFF H., MURPHY F. A. 1975b; Experimental Lassa virus infection in the squirrel monkey. American Journal of Pathology 80:261–272
    [Google Scholar]
  38. WALKER D. H., MCCORMICK J. B., JOHNSON K. M., WEBB P. A., KOMBA-KONO G., ELLIOTT L. H., GARDNER J. J. 1982; Pathologic and virologic study of fatal Lassa fever in man. American Journal of Pathology 107:349–356
    [Google Scholar]
  39. WILSNACK R. E., ROWE W. P. 1964; Immunofluorescent studies of the histopathogenesis of lymphocytic choriomeningitis virus infection. Journal of Experimental Medicine 120:829–840
    [Google Scholar]
  40. ZINKERNAGEL R. M., ALTHAGE A., JENSEN F., STREILEIN J. W., DUNCAN W. R. 1978; Cell-mediated immunity to viruses in hamsters. Federation Proceedings 37:2078–2081
    [Google Scholar]
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