RT Journal Article SR Electronic(1) A1 Niedrig, M. A1 Rabanus, J.-P. A1 Stehr, J. L’Age A1 Gelderblom, H. R. A1 Pauli, G.YR 1988 T1 Monoclonal Antibodies Directed against Human Immunodeficiency Virus (HIV) gag Proteins with Specificity for Conserved Epitopes in HIV-1, HIV-2 and Simian Immunodeficiency Virus JF Journal of General Virology, VO 69 IS 8 SP 2109 OP 2114 DO https://doi.org/10.1099/0022-1317-69-8-2109 PB Microbiology Society, SN 1465-2099, AB Summary Monoclonal antibodies (MAbs) were raised against gag proteins of human immunodeficiency virus type 1 (HIV-1), strain HTLV-IIIB. One of 29 antibodies was specific for p17 of HIV-1. Twenty of 28 MAbs reactive with the major core protein p24 of HIV-1 showed cross-reactivity with HIV-2, and five of these also detected the corresponding antigens of simian immunodeficiency virus (SIVmac). The MAbs were reactive in several tests, i.e. ELISA, immunostaining of Western blots, immunofluorescence, alkaline phosphatase-anti-alkaline phosphatase immunocytochemistry and immunoelectron microscopy. The submembrane protein p17 was clearly localized within the virion., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-8-2109