%0 Journal Article %A Niedrig, M. %A Rabanus, J.-P. %A Stehr, J. L’Age %A Gelderblom, H. R. %A Pauli, G. %T Monoclonal Antibodies Directed against Human Immunodeficiency Virus (HIV) gag Proteins with Specificity for Conserved Epitopes in HIV-1, HIV-2 and Simian Immunodeficiency Virus %D 1988 %J Journal of General Virology, %V 69 %N 8 %P 2109-2114 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-69-8-2109 %K HIV %K SIV %K MAbs %I Microbiology Society, %X Summary Monoclonal antibodies (MAbs) were raised against gag proteins of human immunodeficiency virus type 1 (HIV-1), strain HTLV-IIIB. One of 29 antibodies was specific for p17 of HIV-1. Twenty of 28 MAbs reactive with the major core protein p24 of HIV-1 showed cross-reactivity with HIV-2, and five of these also detected the corresponding antigens of simian immunodeficiency virus (SIVmac). The MAbs were reactive in several tests, i.e. ELISA, immunostaining of Western blots, immunofluorescence, alkaline phosphatase-anti-alkaline phosphatase immunocytochemistry and immunoelectron microscopy. The submembrane protein p17 was clearly localized within the virion. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-8-2109