1887

Abstract

Summary

The potential of immune-stimulating complexes (iscoms), a novel form of antigenic presentation, for the induction of protective immunity against morbillivirus infection was shown by immunizing dogs with canine distemper virus (CDV) iscoms, which contained the fusion (F) protein and a minor amount of the haemagglutinin of the virus. The immunized dogs developed CDV-neutralizing antibodies but, in contrast to non-immunized dogs, did not develop viraemia or clinical signs of infection upon intranasal challenge with the virulent Snyder Hill strain of CDV. Immunization of dogs with measles virus (MV) iscoms, prepared either from affinity-purified MV F protein or from purified whole virus, resulted in partial protection against challenge with CDV. The data presented clearly show that the iscom form of antigenic presentation may be considered a serious candidate for subunit vaccines against morbillivirus infection.

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1988-08-01
2024-12-08
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References

  1. APPEL M. J. G. 1978; Reversion to virulence of attenuated canine distemper virus in vivo and in vitro. Journal of General Virology 41:385–393
    [Google Scholar]
  2. APPEL M. J. G. 1987 Canine distemper virus. Virus Infections of Vertebrates 1133–159 Edited by Horzinek M. C. Amsterdam: Elsevier;
    [Google Scholar]
  3. APPEL M. J. G., JONES O. R. 1967; Use of alveolar macrophages for cultivation of canine distemper virus. Proceedings of the Society for Experimental Biology and Medicine 126:571–574
    [Google Scholar]
  4. APPEL M. J. G., SHEK W. R., SHESHBERADARAN H., NORRBY E. 1984; Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper. Archives of Virology 82:73–82
    [Google Scholar]
  5. BUSSELL R. H., KARZON D. T. 1965; Canine distemper virus in primary and continuous cell lines of human and monkey origin. Archiv fur die gesamte Virusforschung 17:183–202
    [Google Scholar]
  6. COMMITTEE ON ISSUES FOR NEW VACCINE DEVELOPMENT 1985 New Vaccine Development Establishing Priorities 1385–396 Division of Health Promotion and Disease Prevention, Institute of Medicine, National Academy of Sciences, U.S.A. Washington, D.C.: National Academy Press;
    [Google Scholar]
  7. DE VRIES P., VAN BINNENDIJK R. S., VAN DER MAREL P., BEUVERY E. C, VAN WEZEL A. L., VOORMA H. O., UYTDEHAAG F. G. C. M., OSTERHAUS A. D. M. E. 1987; Inhibition of measles virus-induced cell-cell fusion with a monoclonal antibody directed against the haemagglutinin. Viral Immunology 1:25–34
    [Google Scholar]
  8. DE VRIES P., VAN BINNENDIJK R. S., VAN DER MAREL P., VAN WEZEL A. L., VOORMA H. O., SUNDQUIST B., UYTDEHAAG F. G. C. M., OSTERHAUS A. D. M. E. 1988; Measles virus fusion protein presented in an immune-stimulating complex (iscom) induces haemolysis-inhibiting and fusion-inhibiting antibodies, virus-specific T cells and protection in mice. Journal of General Virology 69:549–559
    [Google Scholar]
  9. GILLESPIE J. H. 1974; A study of inactivated distemper virus in the dog. Cornell Veterinary 55:3–8
    [Google Scholar]
  10. HALL W. W., LAMB R. A., CHOPPIN P. W. 1980; The polypeptides of canine distemper virus: synthesis in infected cells and relatedness to the polypeptides of other morbilliviruses. Virology 100:433–449
    [Google Scholar]
  11. HARDWICK J. M., BUSSELL R. H. 1978; Glycoproteins of measles virus under reducing and non-reducing conditions. Journal of Virology 25:687–692
    [Google Scholar]
  12. HOWARD C. R., SUNDQUIST B., ALLAN J., BROWN S. E., CHEN S-H., MOREIN B. 1987; Preparation and properties of immune-stimulating complexes containing hepatitis B virus surface antigen. Journal of General Virology 68:2281–2289
    [Google Scholar]
  13. LAMB R. A., ETKIND P. R., CHOPPIN P. W. 1978; Evidence for a ninth influenza viral polypeptide. Virology 91:60–78
    [Google Scholar]
  14. MOREIN B., SIMONS K. 1985; Subunit vaccines against enveloped viruses: virosomes, micelles and other protein complexes. Vaccine 3:83–93
    [Google Scholar]
  15. MOREIN B., SUNDQUIST B., HOGLUND S., DALSGAARD K., OSTERHAUS A. 1984; Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature, London 308:457–459
    [Google Scholar]
  16. NORRBY E. 1985; Measles vaccination, today and tomorrow. Annales de l’Institut Pasteur/Virologie 136E:561–570
    [Google Scholar]
  17. NORRBY E., APPEL M. J. G. 1980; Humoral immunity to canine distemper after immunization of dogs with inactivated and live measles virus. Archives of Virology 66:169–170
    [Google Scholar]
  18. NORRBY E., GOLLMAR Y. 1972; Appearance and persistence of antibodies against different virus components after regular measles infections. Infection and Immunity 6:240–247
    [Google Scholar]
  19. NORRBY E., ENDERS-RUCKLE G., TER MEULEN V. 1975; Differences in the appearance of antibodies to structural components of measles virus after immunization with inactivated and live virus. Journal of Infectious Diseases 132:262–269
    [Google Scholar]
  20. NORRBY E., UTTER G., ÖRVELL C., APPEL M. 1986; Protection against canine distemper virus in dogs after immunization with isolated fusion protein. Journal of Virology 58:536–541
    [Google Scholar]
  21. ÖRVELL C, SHESHBERADARAN H., NORRBY E. 1985; Preparation and characterization of monoclonal antibodies directed against four structural components of canine distemper virus. Journal of General Virology 66:443–456
    [Google Scholar]
  22. OSTERHAUS A. D. M. E., WEYER K., UYTDEHAAG F., JARRETT D., SUNDQUIST B., MOREIN B. 1985; Induction of protective immune response in cats by vaccination with feline leukemia virus iscoms. Journal of Immunology 135:591–596
    [Google Scholar]
  23. RIMA B. K., BACZKO K., IMAGAWA D. T., TER MEULEN V. 1987; Humoral immune response in dogs with old dog encephalitis and chronic distemper meningo-encephalitis. Journal of General Virology 68:1723–1735
    [Google Scholar]
  24. SCHEID A., CHOPPIN P. W. 1974; Identification of the biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus. Virology 57:475–490
    [Google Scholar]
  25. SCHEID A., CHOPPIN P. W. 1977; Two disulfide-linked chains constitute the active F protein of paramyxoviruses. Virology 80:54–66
    [Google Scholar]
  26. SCHEID A., CALIGULRI L. A., COMPANS R. W., CHOPPIN P. W. 1972; Isolation of paramyxovirus glycoproteins. Association of both hemagglutinating and neuraminidase activities with the larger SV5 glycoprotein. Virology 50:640–652
    [Google Scholar]
  27. VARSANYI T. M., UTTER G., NORRBY E. 1984; Purification, morphology and antigenic characterization of measles virus envelope components. Journal of General Virology 65:355–366
    [Google Scholar]
  28. VARSANYI T. M., MOREIN B., LOVE A., NORRBY E. 1987; Protection against lethal measles virus infection in mice by immune stimulating complexes containing the hemagglutinin or fusion protein. Journal of Virology 61:3896–3901
    [Google Scholar]
  29. WAHREN B., NORDLUND S., AKESSON A., SUNDQVIST V.-A., MOREIN B. 1987; Monocyte and iscom enhancement of cell-mediated response to cytomegalovirus. Medical Microbiology and Immunology 176:13–19
    [Google Scholar]
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