1887

Journal of General Virology header logo

Volume 69, Issue 8

Immunological Conservation between Epstein-Barr Virus and Herpes Simplex Virus Free

Abstract

Summary

We have analysed Epstein-Barr virus (EBV)- and herpes simplex virus (HSV)-infected cells for evidence of antigenic conservation of virus-coded proteins. Immunofluorescence and Western blot analyses of EBV-transformed cell lines demonstrated the presence of proteins that are antigenically related to the HSV alkaline DNase, infected cell-specific protein 34/35, glycoprotein B, thymidine kinase and the major DNA-binding protein. These proteins were characterized on the basis of and possible kinetic class.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antigenic conservation , EBV and HSV
© Society for General Microbiology 1988
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-69-8-2021
1988-08-01
2023-12-05
Loading full text...

Full text loading...

/deliver/fulltext/jgv/69/8/JV0690082021.html?itemId=/content/journal/jgv/10.1099/0022-1317-69-8-2021&mimeType=html&fmt=ahah

References

  1. ALLAUDEEN H. S., BERTINO J. R. 1978; Isolation of a herpes virus-specific DNA polymerase from tissue of an American patient with Burkitt lymphoma. Proceedings of the National Academy of Sciences, U.S.A 75:4504–4508
     [Google Scholar]
  2. ALLAUDEEN H. S., RANI G. 1982; Cellular and Epstein-Barr virus specific DNA polymerase in virus-producing Burkitt’s lymphoma cell lines. Nucleic Acids Research 10:2453–2465
     [Google Scholar]
  3. ARRAND J. R., WALSH-ARRAND J. E., RYMO L. 1983; Cytoplasmic RNA from normal and malignant human cells shows homology to the DNAs of Epstein-Barr virus and human adenoviruses. EMBO Journal 2:1673–1680
     [Google Scholar]
  4. BAER R., BANKIER A. T., BIGGIN M. D., DEININGER P. L., FARRELL P. J., GIBSON T. J., HATFULL G., HUDSON G. S., SATCHWELL S. C, SÉGUIN C, TUFFNELL P. S., BARRELL B. G. 1984; DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature, London 310:207–211
     [Google Scholar]
  5. BANKS L., PURIFOY D. J. M., HURST P.-F., KILLINGTON R. A., POWELL K. L. 1983; Herpes simplex virus nonstructural proteins. IV. Purification of the virus-induced deoxyribonuclease and characterization of the enzyme using monoclonal antibodies. Journal of General Virology 64:2249–2260
     [Google Scholar]
  6. BANKS L. M., VAUGHAN P. J., MEREDITH D., POWELL K. L. 1984; Monoclonal antibodies to herpes simplex virus thymidine kinase. Journal of General Virology 65:1625–1630
     [Google Scholar]
  7. BAUER G. 1983; Quantitative analysis of the cooperative effect between inducers of Epstein-Barr virus antigen synthesis. Journal of General Virology 64:1337–1346
     [Google Scholar]
  8. BERNHEIM A., BERGER R., LENOIR G. 1983; Cytogenic studies on Burkitt’s lymphoma cell lines. Cancer Genetics and Cytogenetics 8:223–229
     [Google Scholar]
  9. BLUE W. T., PLUMMER G. 1973; Antigenic relationships among four herpesviruses. Infection and Immunity 7:1000–1002
     [Google Scholar]
  10. BZIK D. J., FOX B. A., DELUCA N. A., PERSON S. 1984; Nucleotide sequence specifying the glycoprotein gene, gB, of herpes simplex virus type 1. Virology 33:301–314
     [Google Scholar]
  11. CHARTRAND P., CRUMPACKER C. S., SCHAFFER P. A., WILKIE N. M. 1980; Physical and genetical analysis of the herpes simplex virus DNA polymerase locus. Virology 103:311–326
     [Google Scholar]
  12. CLOUGH W. 1979; Deoxyribonuclease activity found in Epstein-Barr virus-producing human lymphoblastoid cells. Biochemistry 18:4517–4521
     [Google Scholar]
  13. CLOUGH W. 1980; An endonuclease isolated from Epstein-Barr virus-producing human lymphoblastoid cells. Proceedings of the National Academy of Sciences, U.S.A 77:6194–6198
     [Google Scholar]
  14. COSTA R. H., DRAPER K. G., BANKS L., POWELL K. L., COHEN G., EISENBERG R., WAGNER E. K. 1983; High-resolution characterisation of herpes simplex virus type 1 transcripts encoding alkaline endonuclease and a 50,000 dalton protein tentatively identified as a capsid protein. Journal of Virology 48:591–603
     [Google Scholar]
  15. COSTA R. M., DRAPER K. G., KELLY T. J., WAGNER E. K. 1985; An unusual spliced herpes simplex virus type 1 transcript with sequence homology to Epstein-Barr virus DNA. Journal of Virology 54:317–328
     [Google Scholar]
  16. CRANAGE M. P., KOUZARIDES T., BANKIER A. T., SATCHWELL S., WESTON K., TOMLINSON P., BARRELL B., HART H., BELL S. E., MINSON A. C., SMITH G. L. 1986; Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus. EMBO Journal 5:3057–3063
     [Google Scholar]
  17. DATTA A. K., FEIGHNY R. J., PAGANO J. S. 1980; Induction of Epstein-Barr virus DNA polymerase by 12-O-tetradecanoylphorbol-13-acetate. Journal of Biological Chemistry 255:5120–5125
     [Google Scholar]
  18. DAVISON A. J., SCOTT J. E. 1986a; The complete DNA sequence of varicella-zoster virus. Journal of General Virology 67:1759–1816
     [Google Scholar]
  19. DAVISON A. J., SCOTT J. E. 1986b; The DNA sequence of the major capsid protein gene of herpes simplex virus type 1. Journal of General Virology 67:2279–2286
     [Google Scholar]
  20. DAVISON A. J., TAYLOR P. 1987; Genetic relations between varicella-zoster virus and Epstein-Barr virus. Journal of General Virology 68:1067–1079
     [Google Scholar]
  21. DAVISON A. J., WILKIE N. M. 1983; Inversion of the two segments of herpes simplex virus genome in intertypic recombinants. Journal of General Virology 64:1–18
     [Google Scholar]
  22. FALK L., DEINHARDT F., NONOYOMA H., WOLFE G. L., BERGHOLZ C, LAPIN B., YAKOVLEVA L., AGBRA V., HENLE G., HENLE W. 1976; Properties of a baboon lymphotrophic herpesvirus related to Epstein-Barr virus. International Journal of Cancer 18:798–803
     [Google Scholar]
  23. FEIGHNY R. J., HENRY B. E. I., DATTA A. K., PAGANO J. S. 1980; Induction of DNA polymerase activity after superinfection of Raji cells with Epstein-Barr virus. Virology 107:415–423
     [Google Scholar]
  24. FRANCKE B., GARRETT B. 1982; The effect of a temperature-sensitive lesion in the alkaline DNase of herpes simplex virus type 2 on the synthesis of viral DNA. Virology 116:116–127
     [Google Scholar]
  25. FRANCKE B., MOSS H., TIMBURY M. C., HAY J. 1978; Alkaline DNase activity in cells infected with a temperature-sensitive mutant of herpes simplex virus type 2. Journal of Virology 26:209–213
     [Google Scholar]
  26. GIBSON T., STOCKWELL P., GINSBERG M., BARRELL B. 1984; Homology between two EBV early genes and HSV ribonucleotide reductase and 38K genes. Nucleic Acids Research 12:5087–5099
     [Google Scholar]
  27. GONG M., OOKA T., MATSUO T., KIEFF E. 1987; Epstein-Barr virus glycoprotein homologous to herpes simplex virus gB. Journal of Virology 61:499–508
     [Google Scholar]
  28. HAYWARD G. F., BINDER R. A., GIUSO D., HAYWARD D., LAFEMINA R. C. 1984; Structural organisation of human herpesvirus DNA molecules. Journal of Investigative Dermatology 83:29–41
     [Google Scholar]
  29. HELLER M., KIEFF E. 1981; Colinearity between the DNAs of Epstein-Barr virus and herpesvirus papio. Journal of Virology 32:821–826
     [Google Scholar]
  30. HENLE W., HENLE G., ADJAC B. A., PEARSON G., WAUBKS R., SCRIBA M. 1970; Differential reactivity of human serums with early antigens induced by Epstein-Barr virus. Science 169:188–191
     [Google Scholar]
  31. HINUMA Y., KOHN M., YAMAGUCHI J., WUDARSKI D. J., BLAKESLEE J. R., GRACE J. T. 1967; Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line. Journal of Virology 1:1045–1051
     [Google Scholar]
  32. HIRAKI S., MYOSHI I., MUSUGI H., KUBONISHI I., MATSUDA Y., NAKAΥAMA T., KISHIMOTO M., CHEN P., KIMURA I. 1977; Establishment of an Epstein-Barr virus determined nuclear antigen-negative human B-cell line from acute lymphoblastic leukaemia. Journal of the National Cancer Institute 59:93–94
     [Google Scholar]
  33. HONESS R. W. 1984; Herpes simplex and ‘the herpes complex’: diverse observations and a unifying hypothesis. Journal of General Virology 65:2077–2107
     [Google Scholar]
  34. HONESS R. W., WATSON D. H. 1977; Unity and diversity in the herpesviruses. Journal of General Virology 37:15–37
     [Google Scholar]
  35. HOWLEY P. M., ISRAEL M. A., LAW M.-F., MARTIN M. A. 1979; A rapid method for detecting and mapping between heterologous DNAs. Journal of Biological Chemistry 254:4876–4883
     [Google Scholar]
  36. HUMMEL M., KIEFF E. 1982; Mapping of polypeptides encoded by the Epstein-Barr virus genome in productive infection. Proceedings of the National Academy of Sciences, U.S.A 79:5698–5702
     [Google Scholar]
  37. JENSON A. B., ROSENTHAL J. D., OLSON C, PASS F., LANCASTER W. D., SHAH K. 1980; Immunologic relatedness of papillomaviruses from different species. Journal of the National Cancer Institute 64:495–500
     [Google Scholar]
  38. KIEFF E., DAMBAUGH T., HUMMEL M., HELLER M. 1983 Epstein-Barr virus transformation and replication. Advances in Viral Oncology 3133–175 Edited by Klein G. New York: Raven Press;
     [Google Scholar]
  39. KILLINGTON R. A., YEO I., HONESS R. W., WATSON D. H., DUNCAN B. E., HALLIBURTON I. W., MUMFORD J. 1977; Comparative analyses of the proteins and antigens of five herpesviruses. Journal of General Virology 37:297–310
     [Google Scholar]
  40. KOUZARIDES T., BANKIER A. T., SATCHWELL S. C, WESTON K., TOMLINSON P., BARRELL B. G. 1987; Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene. Journal of Virology 61:125–133
     [Google Scholar]
  41. LEE Y. S., TANAKA A., LAU R. Y., NONOYAMA M., RABIN H. 1981; Linkage map of the fragments of herpesvirus papio DNA. Journal of Virology 33:710–720
     [Google Scholar]
  42. LITTLER E., YEO J., KILLINGTON R. A., PURIFOY D. J. M., POWELL K. L. 1981; Antigenic and structural conservation of herpesvirus DNA-binding proteins. Journal of General Virology 56:409–419
     [Google Scholar]
  43. LITTLER E., ZEUTHEN J., MCBRIDE A. A., TROST SORENSEN E., POWELL K. L., WALSH-ARRAND J. E., ARRAND J. R. 1986; Identification of an Epstein-Barr virus coded thymidine kinase. EMBO Journal 5:1959–1969
     [Google Scholar]
  44. MCGEOCH D. J., DAVISON A. J. 1986; DNA sequence of the herpes simplex type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus. Nucleic Acids Research 11:4281–4292
     [Google Scholar]
  45. MCGEOCH D. I., DOLAN A., FRAME M. C. 1986; DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes. Nucleic Acids Research 14:3435–3448
     [Google Scholar]
  46. MILLER G., LIPMAN M. 1973; Release of infectious Epstein-Barr virus by transformed marmoset leukocytes. Proceedings of the National Academy of Sciences, U.S.A 70:190–194
     [Google Scholar]
  47. MILLER G., COOPE D., NIEDERMAN J., PAGANO J. 1976; Biological properties and viral surface antigens of Burkitt lymphoma- and mononucleosis-derived strains of Epstein-Barr virus released from transformed marmoset cells. Journal of Virology 18:1071–1080
     [Google Scholar]
  48. MILLER R. L., GLASER R., RAPP F. 1977; Studies on an Epstein-Barr virus-induced DNA polymerase. Virology 76:494–502
     [Google Scholar]
  49. MOSS H. 1986; The herpes simplex virus type 2 alkaline DNase activity is essential for replication and growth. Journal of General Virology 67:1173–1178
     [Google Scholar]
  50. MOSS H., CHARTRAND P., TIMBURY M. C., HAY J. 1979; Mutant of herpes simplex virus type 2 with temperature-sensitive lesions affecting virion thermostability and DNase activity: identification of the lethal mutation and physical mapping of the nuc” lesion. Journal of Virology 32:140–146
     [Google Scholar]
  51. NORRBY E. 1966; The relationship between soluble antigens and the virion of adenovirus type 3.1. Morphological characteristics. Virology 28:236–240
     [Google Scholar]
  52. OOKA T., LENOIR G., DAILLIE J. 1979; Characterization of an Epstein-Barr virus-induced DNA polymerase. Journal of Virology 29:1–10
     [Google Scholar]
  53. PEARSON G. 1980 Epstein-Barr virus: immunology. Viral Oncology739–767 Edited by Klein G. New York: Raven Press;
     [Google Scholar]
  54. PEARSON G., VROMAN B., CHASE B., SCULLEY T., HUMMEL M., KIEFF E. 1983; Identification of polypeptide components of the Epstein-Barr virus early antigen complex with monoclonal antibodies. Journal of Virology 47:193–201
     [Google Scholar]
  55. PELLETT P. E., BIGGIN M. D., BARRELL B., ROIZMAN B. 1985; Epstein-Barr virus may encode a protein showing significant amino acid and predicted secondary structure homology with glycoprotein B of herpes simplex virus 1. Journal of Virology 56:807–813
     [Google Scholar]
  56. PERSSON R. H., BACCHETTI S., SMILEY J. R. 1985; Cells that constitutively express the herpes simplex virus immediate early protein ICP4 allow efficient activation of viral delayed early genes in trans. Journal of Virology 54:414–421
     [Google Scholar]
  57. POWELL K. L., PURIFOY D. J. M. 1977; Non-structural proteins of herpes simplex virus. I. Purification of the induced DNA polymerase. Journal of Virology 24:618–626
     [Google Scholar]
  58. POWELL K. L., LITTLER E., PURIFOY D. J. M. 1981; Non-structural proteins of herpes simplex virus. II. Major virus specific DNA binding protein. Journal of Virology 39:894–902
     [Google Scholar]
  59. PRACHOVA K., ROUBAL J., AGRBA V. Z., TIMANOSKAYA V. V., VOEVODIN A. F. 1983; Functional complementation between Epstein-Bar virus and herpesvirus papio. Intervirology 19:52–55
     [Google Scholar]
  60. PULVERTAFT R. J. V. 1965; A study of malignant tumours in Nigeria by short term tissue culture. Journal of Clinical Pathology 18:261–273
     [Google Scholar]
  61. PURIFOY D. J. M., POWELL K. L. 1976; DNA-binding proteins induced by herpes simplex virus type-2 in Hep-2 cells. Journal of Virology 19:717–731
     [Google Scholar]
  62. QUINN J. P., MCGEOCH D. J. 1985; DNA sequence of the region in the genome of herpes simplex type 1 containing the genes for DNA polymerase and the major DNA binding protein. Nucleic Acids Research 13:8143–8163
     [Google Scholar]
  63. RABIN H., NEUBAUER R. H., HOPKINS R. F. III, DZHIKIDZE E. K., SHEUTSARA V., LAPIN B. A. 1977; Transforming activity and antigenicity of an Epstein-Barr-like virus from lymphoblastoid cell lines of baboons with lymphoid disease. Intervirology 8:240–245
     [Google Scholar]
  64. REEDMAN B. M., KLEIN G. 1973; Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing-antigen in producer and non-producer lymphoblastoid cell lines. International Journal of Cancer 11:499–520
     [Google Scholar]
  65. ROIZMAN B. 1982 The family Herpesviridae: general description, taxonomy and classification. The Herpesviruses 1,1–23 Edited by Roizman B. New York & London: Plenum Press;
     [Google Scholar]
  66. SEIBL R., WOLF H. 1985; Mapping of Epstein-Barr virus proteins on the genome by translation of hybrid-selected RNA from induced P3HR1 cells and induced Raji ceils. Virology 141:1–13
     [Google Scholar]
  67. SNOWDEN B. W., KINCHINGTON P. R., POWELL K. L., HALLIBURTON I. W. 1985; Antigenic and biochemical analysis of gB of herpes simplex virus type 1 and type 2 and of cross-reacting glycoproteins induced by bovine mammillitis virus and equine herpesvirus type 1. Journal of General Virology 66:231–247
     [Google Scholar]
  68. STERZ M., LUDWIG H., ROTT R. 1974; Immunologic and genetic relationship between herpes simplex virus and bovine herpes mammillitis virus. Intervirology 2:1–13
     [Google Scholar]
  69. STINCHCOMBE T., CLOUGH W. 1985; Epstein-Barr virus induces a unique pyrimidine deoxynucleoside kinase activity in superinfected and virus-producer B cell lines. Biochemistry 24:2027–2033
     [Google Scholar]
  70. TAN R-S., DATTA A. K., CHENG Y-C. 1982a; Identification and characterisation of a DNase induced by Epstein-Barr virus. Journal of Virology 44:893–899
     [Google Scholar]
  71. TAN R-S., CHENG Y-C, NAEGELE R. F., HENLE W., GLASER R., CHAMPION J. 1982b; Antibody responses to Epstein-Barr virus specific DNase in relation to the prognosis of juvenile patients with nasopharyngeal carcinoma. International Journal of Cancer 30:561–565
     [Google Scholar]
  72. TOWBIN H., STAEHELIN T., GORDON J. 1979; Electrophoretic transfer of proteins from Polyacrylamide to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, U.S.A 76:4350–4354
     [Google Scholar]
  73. VAUGHAN P. J., BANKS L. M., PURIFOY D. J. M., POWELL K. L. 1984; Interactions between herpes simplex virus DNA-binding proteins. Journal of General Virology 65:2033–2041
     [Google Scholar]
  74. VAUGHAN P. I., PURIFOY D. L. M., POWELL K. L. 1985; DNA-binding protein associated with herpes simplex virus DNA polymerase. Journal of Virology 53:501–508
     [Google Scholar]
  75. WAGNER M. J., SHARP J. A., SUMMERS W. C. 1981; Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1. Proceedings of the National Academy of Sciences, U.S.A 78:1441–1445
     [Google Scholar]
  76. WATSON D. H., WILDY P., HARVEY B. A. M., SHEDDEN W. I. H. 1967; Serological relationships among viruses of the herpes group. Journal of General Virology 1:139–141
     [Google Scholar]
  77. ΥEO J., KILLINGTON R. A., WATSON D. H., POWELL K. L. 1981; Studies on cross reactive antigens in the herpesviruses. Virology 108:256–266
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-69-8-2021
Loading
Immunological Conservation between Epstein-Barr Virus and Herpes Simplex Virus
J. Gen. Virol. 69, 2021 (1988); https://doi.org/10.1099/0022-1317-69-8-2021
/content/journal/jgv/10.1099/0022-1317-69-8-2021
/content/journal/jgv/10.1099/0022-1317-69-8-2021
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error