1887

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Volume 69, Issue 8

Effect of Macrophage Activation on Resistance of Mouse Peritoneal Macrophages to Infection with Herpes Simplex Virus Types 1 and 2 Free

Abstract

Summary

To define the effect of heterogeneity of murine peritoneal macrophages (Mø) on intrinsic resistance to herpes simplex virus (HSV) infection, several Mø populations were characterized for their response to infection with HSV type 1 (HSV-1) and HSV-2. Steady-state resident Mø (Res Mø) were compared in parallel with Mø activated with (now designated ) (CP Mø) and thioglycollate-elicited inflammatory Mø (TG Mø). Res Mø were completely non-permissive for productive virus infection and showed no c.p.e. The intrinsic resistance of CP Mø to HSV infection was similar to that of Res Mø, in that the infection was non-productive for infectious virus, but CP Mø showed marked c.p.e. TG Mø showed semi-permissiveness, with virus yields at least 10-fold higher than those in Res Mø and CP Mø, and marked c.p.e. The three distinct intrinsic response patterns were maintained regardless of whether Mø were derived from CD-1 or B6C3F1 mice, or whether the infecting virus was HSV-1 or HSV-2. To define the level at which Mø restrict HSV replication, immunofluorescence assays for viral antigens and hybridization analyses for viral DNA were performed. All Mø populations showed immediate early and early virus polypeptides. Res Mø and CP Mø showed no viral DNA replication, but TG Mø showed moderate levels of viral DNA synthesis that paralleled the infectious virus titres produced. Investigation of the mechanism for the heterogeneous intrinsic antiviral response among the Mø revealed that interferon was not involved, because antiserum to mouse α/β interferon did not alter the intrinsic resistance patterns. Induction of c.p.e. in Mø required live, replication-competent HSV. The involvement of tumour necrosis factor (TNF) in c.p.e. was found to be unlikely; no significant amounts of TNF were detected in the culture medium of the Mø, and inclusion of anti-TNF antibody did not inhibit c.p.e.

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Keyword(s): HSV , macrophages and resistance
© Society for General Microbiology 1988
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1988-08-01
2024-04-24
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References

  1. ACKERMANN M., BRAUN D. K., PEREIRA L., ROIZMAN B. 1984; Characterization of HSV-1 proteins 0, 4 and 27 with monoclonal antibodies. Journal of Virology 52:108–118
     [Google Scholar]
  2. ACKERMANN M. F., MARK R., CHAKRABORTY P. R., MORAHAN P. S. 1986; Effects of diethylstilbestrol on Propionibacterium acnes immunomodulation: inhibition of macrophage activation and antitumor activity. Journal of Leukocyte Biology 40:549–559
     [Google Scholar]
  3. BELARDELLI F., VIGNAUX F., PROIETTI E., GRESSER I. 1984; Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus and encephalomyocarditis virus. Proceedings of the National Academy of Sciences, U.S.A 81:602–606
     [Google Scholar]
  4. BELL G. I., KARAM J. H., RUTTER W. J. 1981; Polymorphic DNA region adjacent to the 5′ end of the human insulin gene. Proceedings of the National Academy of Sciences, U.S.A 78:5759–5763
     [Google Scholar]
  5. BERENT S. L., TORCZYNSKI R. M., BOLLON A. P. 1986; Sendai virus induces high levels of tumor necrosis factor mRNA in human peripheral blood leukocytes. Nucleic Acids Research 14:8997–9015
     [Google Scholar]
  6. BIELEFELDT OHMANN H., GILCHRIST J. E., BABIUK L. A. 1984; Effect of recombinant DNA-produced bovine interferon alpha (BoIFN-α1) on the interaction between bovine alveolar macrophages and bovine herpesvirus type 1. Journal of General Virology 65:1487–1495
     [Google Scholar]
  7. BRÄUTIGAM A. R., DUTKO F. J., OLDING L. B., OLDSTONE M. B. A. 1979; Pathogenesis of murine cytomegalovirus infection: the macrophage as a permissive cell for cytomegalovirus infection, replication and latency. Journal of General Virology 44:349–359
     [Google Scholar]
  8. BREINIG M. C, WRIGHT L. L., MCGEORGE M. B., MORAHAN P. S. 1978; Resistance to vaginal or systemic infection with herpes simplex virus type 2. Archives of Virology 57:25–34
     [Google Scholar]
  9. DALTON B. J., PAUKER K. 1981; Preparation and absorption of antiserum against mouse L cell interferon. Methods in Enzymology 79:582–585
     [Google Scholar]
  10. DECKER T., LOHMANN-MATTHES M.-L., GIFFORD G. E. 1987; Cell associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages. Journal of Immunology 138:957–962
     [Google Scholar]
  11. DEMPSEY W. L., SMITH A. L., MORAHAN P. S. 1986; Effect of inapparent murine hepatitis virus infection on macrophages and host resistance. Journal of Leukocyte Biology 39:559–565
     [Google Scholar]
  12. DEMPSEY W. L., HWU P., RUSSELL D. H., MORAHAN P. S. 1988; Comparison of macrophage populations for polyamine content and ectoenzyme phenotype. Life Sciences 42:2019–2027
     [Google Scholar]
  13. DOMKE-OPITZ I., STRAUB P., KIRCHNER H. 1986; Effect of interferon on replication of herpes simplex virus types 1 and 2 in human macrophages. Journal of Virology 60:37–42
     [Google Scholar]
  14. ELLERMANN-ERIKSEN S., LIBERTO M. C, IANNELLO D., MOGENSEN S. C. 1986; X-linkage of the early in vitro α/β interferon response of mouse peritoneal macrophages to herpes simplex virus type 2. Journal of General Virology 67:1025–1033
     [Google Scholar]
  15. GENDELMAN H. E., NARAYAN O., KENNEDY-STOSKOPF S., KENNEDY P. G. E., GHOTBI Z., CLEMENTS J. E., STANLEY J., PEZECHPOUR G. 1986; Tropism of sheep lentiviruses of monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. Journal of Virology 58:68–74
     [Google Scholar]
  16. GIFFORD G. E., LOHMANN-MATTHES M.-L. 1986; Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate induced peritoneal murine macrophages. International Journal of Cancer 38:135–137
     [Google Scholar]
  17. GOLDIN A. L., SANDRI-GOLDIN R. M., LEVINE M., GLORIOSO J. C. 1981; Cloning of herpes simplex virus type 1 sequences representing the whole genome. Journal of Virology 38:50–58
     [Google Scholar]
  18. GRESSER L., VIGNAUX F., BELARDELLI F., TOVEY M. G., MAUNOURY M. T. 1984; Injection of mice with antibody to mouse interferon α/β decreases the level of 2′-5′ oligoadenylate synthetase in peritoneal macrophages. Virology 53:221–227
     [Google Scholar]
  19. JOHNSON R. T. 1964; The pathogenesis of herpes virus encephalitis. II. A cellular basis for the development of resistance with age. Journal of Experimental Medicine 120:359–374
     [Google Scholar]
  20. KAPLAN A. M., MORAHAN P. S. 1976; Macrophage mediated tumor cell cytotoxicity. Annals of the New York Academy of Sciences 276:135–145
     [Google Scholar]
  21. KIRCHNER H., HIRT H. M., MUNK K. 1977; Protection against herpes simplex virus infection in mice by Corynebacterium parvum. Infection and Immunity 16:9–11
     [Google Scholar]
  22. KOFF W. C., FANN A. F. 1986; Human tumor necrosis factor-alpha kills herpesvirus infected but not normal cells. Lymphokine Research 5:215–221
     [Google Scholar]
  23. KRAMER S. M., CARVER M. E. 1986; Serum free in vitro bioassay for the detection of tumor necrosis factor. Journal of Immunological Methods 93:201–206
     [Google Scholar]
  24. LEARY K. R., CONNOR J. R., MORAHAN P. S. 1985; Comparison of herpes simplex virus type 1 DNA replication and virus production in murine bone marrow-derived and resident peritoneal macrophages. Journal of General Virology 66:1123–1129
     [Google Scholar]
  25. LOPEZ C., DUDAS G. 1979; Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice. Infection and Immunity 23:432–437
     [Google Scholar]
  26. MANIATIS T., FRITSCH E. F., SAMBROOK J. 1982 Molecular Cloning: A Laboratory Manual New York: Cold Spring Harbor Laboratory;
     [Google Scholar]
  27. MESTIAN J., DIGEL W., MITTNACHT S., HILLES H., BLOHM D., MOLLER A., JACOBSEN H., KIRCHNER H. 1986; Antiviral effects of recombinant tumor necrosis factor in vivo. Nature, London 323:816–818
     [Google Scholar]
  28. MORAHAN P. S. 1984 Interactions of herpesviruses with mononuclear phagocytes. Immunobiology of Herpes Simplex Virus Infection71–89 Edited by Rouse B. T., Lopez C. Boca Raton: CRC Press;
     [Google Scholar]
  29. MORAHAN P. S., MURASKO D. M. 1988 Natural immunity to virus infections. Natural Immunity Edited by Nelson D. S. Sydney: Academic Press; in press
    [Google Scholar]
  30. MORAHAN P. S., GLASGOW L. A., CRANE J. L. JR, KERN E. R. 1977a; Comparison of antiviral and antitumor activity of activated macrophages. Cellular Immunology 28:404–415
     [Google Scholar]
  31. MORAHAN P. S., KERN E. R., GLASGOW L. A. 1977b; Immunomodulator induced resistance against herpes simplex virus. Proceedings of the Society for Experimental Biology and Medicine 154:615–620
     [Google Scholar]
  32. MORAHAN P. S., ROZNER M. A., JESSEE E. J. 1982; Effect of elicitation on peritoneal macrophage subpopulations: size distributions, ectoenzyme phenotypes and antitumor activity. International Journalof’Cancer 30:787–794
     [Google Scholar]
  33. MORAHAN P. S., CONNOR J. R., LEARY K. R. 1985; Viruses and the versatile macrophage. British Medical Bulletin 41:15–21
     [Google Scholar]
  34. MORAHAN P. S., VOLKMAN A., MELNICOFF M., DEMPSEY W. L. 1988 Macrophage heterogeneity. Macrophages and Cancer Edited by Heppner G., Fulton A. Boca Raton: CRC Press; in press
    [Google Scholar]
  35. MORSE S. S., MORAHAN P. S. 1981; Activated macrophages mediate interferon independent inhibition of herpes simplex virus. Cellular Immunology 58:72–77
     [Google Scholar]
  36. NISHIOKA Y., SILVERSTEIN S. 1978; Requirement of protein synthesis for the degradation of host mRNA in Friend erythroleukemia cells infected with herpes simplex virus type 1. Journal of Virology 27:619–627
     [Google Scholar]
  37. PAUKER K., DALTON B. J., OGBURN C. A., TORMA E. 1975; Multiple active sites on human interferons. Proceedings of the National Academy of Sciences, U.S.A 72:4587–4591
     [Google Scholar]
  38. RIGBY P. W. J., DIECKMANN M., RHODES C., BERG P. 1977; Labelling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. Journal of Molecular Biology 113:237–251
     [Google Scholar]
  39. ROSE R. M., WASSERMAN A. S., WEISER W. Y., REMOLD H. G. 1986; An acidic lymphokine distinct from interferon-gamma inhibits the replication of herpes simplex virus in human pulmonary macrophages. Cellular Immunology 97:397–406
     [Google Scholar]
  40. SCHEK N., BACHENHEIMER S. L. 1985; Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells. Journal of Virology 55:601–610
     [Google Scholar]
  41. SCHULLER G. B., MORAHAN P. S. 1977; Cellular and serum involvement in protection against Friend leukemia virus. Cancer Research 37:4064–4069
     [Google Scholar]
  42. STEVENS J. G., COOK M. L. 1971; Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. Journal of Experimental Medicine 133:19–38
     [Google Scholar]
  43. STRAUB P., DOMKE I., KIRCHNER H., JACOBSEN H., PANET A. 1986; Synthesis of herpes simplex virus proteins and nucleic acids in interferon treated macrophages. Virology 150:411–418
     [Google Scholar]
  44. SYDISKIS R. J., ROIZMAN B. 1967; The disaggregation of host polysomes in productive and abortive infection with herpes simplex virus. Virology 32:678–686
     [Google Scholar]
  45. TENNEY D. J., MORAHAN P. S. 1987; Effects of differentiation of human macrophage-like U937 cells on intrinsic resistance to herpes simplex virus type 1. Journal of Immunology 139:3076–3083
     [Google Scholar]
  46. TUSHINSKI R. J., OLIVER I. T., GUILBERT L. G., TYNAN P. W., WARNER J. R., STANLEY E. R. 1982; Survival of mononuclear phagocytes depends on a lineage specific growth factor that the differentiated cells selectively destroy. Cell 28:71–81
     [Google Scholar]
  47. URBAN J. L., SHEPARD H. M., ROTHSTEIN J. L., SUGARMAN B. I., SCHREIBER H. 1986; Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages. Proceedings of the National Academy of Sciences, U.S.A 83:5233–5237
     [Google Scholar]
  48. VAN DER MEER J. W. M., VAN DE GIVELS J. F., VAN FURTH R. 1983; Characteristics of long term cultures of proliferating mononuclear phagocytes from bone marrow. Journal of the Reticuloendothelial Society 34:203–225
     [Google Scholar]
  49. VARESIO L., CLAYTON M., RADZIOCH D., BONVINI E. 1987; Selective inhibition of 28S ribosomal RNA in macrophages activated by interferon-gamma or -beta. Journal of Immunology 132:2683–2687
     [Google Scholar]
  50. VOGEL S. N., FERTSCH D. 1987; Macrophages from endotoxin-hyporesponsive (Lpsd) C3H/HeJ mice are permissive for vesicular stomatitis virus because of reduced levels of endogenous interferon: possible mechanisms for natural resistance to infection. Journal of Virology 61:812–818
     [Google Scholar]
  51. WONG H. W., GOEDDEL D. V. 1986; Tumour necrosis factors α and β inhibit virus replication and synergize with interferon. Nature, London 323:819–823
     [Google Scholar]
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Effect of Macrophage Activation on Resistance of Mouse Peritoneal Macrophages to Infection with Herpes Simplex Virus Types 1 and 2
J. Gen. Virol. 69, 1999 (1988); https://doi.org/10.1099/0022-1317-69-8-1999
/content/journal/jgv/10.1099/0022-1317-69-8-1999
/content/journal/jgv/10.1099/0022-1317-69-8-1999
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