1887

Abstract

Summary

The U937 monocytic cell line was used to determine whether antibodies could facilitate infection and replication of the arenaviruses, Pichinde virus (PV) and Lassa fever virus (LFV). When high dilutions of PV-immune serum were added to cultures simultaneously with PV inoculum, virus replication was dramatically (1000-fold) increased. Low dilutions of this antiserum neutralized the virus. LFV also replicated in U937 cells. The presence of LFV-specific immune serum in the growth medium increased the viral titre as much as 10000-fold. Addition of heat-aggregated IgG partially inhibited antibody-mediated enhancement, probably by inhibiting the binding of immune complexes to the monocytic cells.

Keyword(s): arenavirus , LFV and PV
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1988-07-01
2024-03-29
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References

  1. BARRETT A. D. T., GOULD E. A. 1986; Antibody-mediated early death in vivo after infection with yellow fever virus. Journal of General Virology 67:2539–2542
    [Google Scholar]
  2. BRANDT W. E., MCCOWN J. M., GENTRY M. K., RUSSELL P. K. 1982; Infection enhancement of dengue type 2 virus in the U-937 cell line antibodies to flavivirus cross-reactive determinants. Infection and Immunity 36:1036–1041
    [Google Scholar]
  3. BURSTIN S. J., BRANDRISS M. W., SCHLESINGER J. J. 1983; Infection of a macrophage-like cell line, P388D, with reovirus; effects of immune ascitic fluids and monoclonal antibodies on neutralization and on enhancement of viral growth. Journal of Immunology 130:2915–2919
    [Google Scholar]
  4. CARDOSA M. J., GORDON S., HIRSCH S., SPRINGER T. A., PORTERFIELD J. S. 1986; Interaction of West Nile virus with primary murine macrophages: role of cell activation and receptors for antibody and complement. Journal of Virology 57:952–959
    [Google Scholar]
  5. EDWARDS R. L., RICKLES F. R. 1980; The role of human T cells (and T cell products) for monocyte tissue factor generation. Journal of Immunology 125:606–609
    [Google Scholar]
  6. HALSTEAD S. B. 1979; In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody. Journal of Infectious Diseases 140:537–543
    [Google Scholar]
  7. HALSTEAD S. B., O’ROURKE E. J. 1977a; Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. Journal of Experimental Medicine 146:201–217
    [Google Scholar]
  8. HALSTEAD S. B., O’ROURKE E. J. 1977b; Antibody-enhanced dengue virus infection in primate leukocytes. Nature, London 265:739–741
    [Google Scholar]
  9. HALSTEAD S. B., SHOTWELL H., CASALS J. 1973; Studies on the pathogenesis of dengue infection in monkeys. II. Clinical laboratory responses in heterologous infection. Journal of Infectious Diseases 128:15–22
    [Google Scholar]
  10. HELIN H. 1986; Macrophage procoagulant factors - mediators of inflammatory and neoplastin tissue lesions. Medical Biology 64:167–176
    [Google Scholar]
  11. HOTTA H., WILHARTA A. S., HOTTA S. 1984; Antibody-mediated enhancement of dengue virus infection in mouse macrophage cell lines, Mkl and Mml (41802). Proceedings of the Society for Experimental Biology and Medicine 175:320–327
    [Google Scholar]
  12. JAHRLING P. B. 1983; Protection of Lassa virus-infected guinea pigs with Lassa-immune plasma of guinea pig, primate, and human origin. Journal of Medical Virology 12:93–102
    [Google Scholar]
  13. JAHRLING P. B., PETERS C. J. 1984; Passive antibody therapy of Lassa fever in cynomolgous monkeys: importance of neutralizing antibody and Lassa virus strain. Infection and Immunity 44:528–533
    [Google Scholar]
  14. JAHRLING P. B., HESSE R. A., RHODERICK J. B., ELWELL M. A., MOE J. B. 1981; Pathogenesis of a Pichinde virus strain adapted to produce lethal infections in guinea pigs. Infection and Immunity 32:771–778
    [Google Scholar]
  15. KING A. A., SANDS J. J., PORTERFIELD J. S. 1984; Antibody-mediated enhancement of rabies virus infection in a mouse macrophage cell line (P388D1). Journal of General Virology 65:1091–1093
    [Google Scholar]
  16. LEVY G. A., SCHWART B. S., EDGINGTON T. S. 1981; The kinetics and metabolic requirements for direct lymphocyte induction of human procoagulant monokines by bacterial lipopolysaccharide. Journal of Immunology 127:357–363
    [Google Scholar]
  17. MIMS C A. 1986; Interactions of viruses with the immune system. Clinical and Experimental Immunology 66:1–16
    [Google Scholar]
  18. MOGENSEN S. C. 1979; Role of macrophages in natural resistance to virus infections. Microbiological Reviews 43:1–26
    [Google Scholar]
  19. MORAHAN P. S., CONNOR J. R., LEARY K. R. 1985; Viruses and the versatile macrophage. British Medical Bulletin 41:15–21
    [Google Scholar]
  20. PEIRIS J. S. M., PORTERFIELD J. S. 1979; Antibody-mediated enhancement of flavivirus replication in macrophage-like cell lines. Nature, London 282:509–511
    [Google Scholar]
  21. PEIRIS J. S. M., GORDON S., UNKELESS J. C., PORTERFIELD J. S. 1981; Monoclonal anti-Fc receptor IgG blocks antibody enhancement of viral replication in macrophages. Nature, London 289:189–191
    [Google Scholar]
  22. PEIRIS J. S. M., PORTERFIELD J. S., ROEHRIG J. T. 1982; Monoclonal antibodies against the flavivirus West Nile. Journal of General Virology 58:283–289
    [Google Scholar]
  23. PETERS C. J. 1984 Arenaviruses. Textbook of Human Virology513–545 Edited by Belshe R. B. Littleton: PSG Publishing Co;
    [Google Scholar]
  24. PORTERFIELD J. S. 1986; Antibody-dependent enhancement of viral infectivity. Advances in Virus Research 31:335–355
    [Google Scholar]
  25. SCHLESINGER J. J., BRANDRISS M. W. 1981; Growth of 17D yellow fever virus in macrophage-like line, U937: role of Fc and viral receptors in antibody-mediated infection. Journal of Immunology 127:659–665
    [Google Scholar]
  26. SNYDERMAN R., PIKE M. C, FISCHER D. G., KOREN H. S. 1977; Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. Journal of Immunology 119:2060–2066
    [Google Scholar]
  27. UNKELESS J. C., EISEN H. N. 1975; Binding of monomeric immunoglobulins to Fc receptors of mouse macrophages. Journal of Experimental Medicine 142:1520–1533
    [Google Scholar]
  28. WALKER D. H., MCCORMICK J. B., JOHNSON K. M., WEBB P. A., KOMBA-KONO G., ELIOTT L. H., GARDNER J. J. 1982; Pathologic and virologie study of fatal Lassa fever in man. American Journal of Pathology 107:349–356
    [Google Scholar]
  29. WHITE H. A. 1972; Lassa fever - a study of 23 hospital cases. Transactions of the Royal Society of Tropical Medicine and Hygiene 66:390–398
    [Google Scholar]
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