%0 Journal Article %A McLaughlin-Taylor, Elizabeth %A Willey, Dru E. %A Cantin, Edouard M. %A Eberle, R. %A Moss, Bernard %A Openshaw, Harry %T A Recombinant Vaccinia Virus Expressing Herpes Simplex Virus Type 1 Glycoprotein B Induces Cytotoxic T Lymphocytes in Mice %D 1988 %J Journal of General Virology, %V 69 %N 7 %P 1731-1734 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-69-7-1731 %K vaccinia virus %K HSV-1 glycoprotein B %K cytotoxic T cells %I Microbiology Society, %X Summary Spleen cells from BALB/c (H-2d) mice vaccinated with vgB11, a recombinant vaccinia virus which expresses glycoprotein B (gB) of herpes simplex virus type 1 (HSV-1), lysed EMT6 (H-2d) target cells infected with vgB11 or with HSV-1 but did not lyse uninfected EMT6 cells or infected L-929 (H-2k) target cells. Unlabelled target cell competition of lysis showed that only syngeneic cells infected with vgB11 or HSV-1 inhibited lysis of radiolabelled HSV-1-infected targets. These results demonstrate that vgB11 induces H-2-restricted anti-HSV-1 cytotoxic T lymphocytes and that gB is the target antigen. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-7-1731