1887

Journal of General Virology header logo

Volume 69, Issue 6

Is Vertical Transmission Sufficient to Maintain Junin Virus in Nature? Free

Abstract

Summary

The quantitative contribution of vertical transmission to the prevalence rate of Junin virus infection in subsequent generations of its natural reservoir, , was analysed. Data on mortality and reproduction of infected at birth with a wild strain of Junin virus were used to estimate the infection-dependent relative survival rate (β = 0.4849) and relative fertility of the infected host (α = 0.2088). Prevalence rates of infection, obtained by mathematical simulation in optimal conditions of vertical transfer, dropped steadily to zero in a few generations. Vertical transmission was found to be insufficient to overcome the effect of highly depressed survival and fertility of the infected host and maintain a stabilized prevalence of Junin virus infection in successive generations; this suggested that viral maintenance is mainly dependent upon horizontal transmission.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Argentine haemorrhagic fever , Calomys , Junin virus and transmission
© Society for General Microbiology 1988
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-69-6-1437
1988-06-01
2024-12-08
Loading full text...

Full text loading...

/deliver/fulltext/jgv/69/6/JV0690061437.html?itemId=/content/journal/jgv/10.1099/0022-1317-69-6-1437&mimeType=html&fmt=ahah

References

  1. ANDERSON R. M., MAY R. M. 1979; Population biology of infectious diseases: part I. Nature, London 280:361–367
     [Google Scholar]
  2. FINE P. E. M. 1975; Vectors and vertical transmission: an epidemiological perspective. Annals of the New York Academy of Sciences 266:173–194
     [Google Scholar]
  3. FINE P. E. M., SYLVESTER E. S. 1978; Calculation of vertical transmission rates of infection, illustrated with data on an aphid-borne virus. American Naturalist 112:781–786
     [Google Scholar]
  4. GROSS L. 1951; Pathogenic properties and ‘vertical transmission’ of the mouse leukemia agent. Proceedings of the Society for Experimental Biology and Medicine 78:342–348
     [Google Scholar]
  5. MERANI M. S., HODARA V. L., ROLDÂN E. R. S., QUINTANS C. 1988; Reproductive aspects of Calomys musculinus and Calomys callidus (Rodentia, Cricetidae) under laboratory conditions. Laboratory Animals in press
    [Google Scholar]
  6. MIMS C. A. 1981; Vertical transmission of viruses. Microbiological Reviews 45:267–286
     [Google Scholar]
  7. SABATTINI M. S., GONZALEZ L. E., CRESPO J. A. 1967; Aislamiento de virus Junin en roedores silvestres de la provincia de Córdoba. Segundas Jornadas Entomoepidemiológicas Argentinas 3:365–373
     [Google Scholar]
  8. SABATTINI M. S., GONZALEZ DE RIOS L. E., DIAZ G., VEGA V. R. 1977; Infección natural y experimental de roedores con virus Junin. Medicina, Buenos Aires 37:149–161
     [Google Scholar]
  9. VRRULLO A. D., MERANI M. S. 1987; Mecanismos de transmisión del virus Junin en su reservorio natural, Calomys musculinus. Medicina, Buenos Aires 47:440
     [Google Scholar]
  10. VITULLO A. D., HODARA V. L., MERANI M. S. 1987; Effect of persistent infection with Junin virus on growth and reproduction of its natural reservoir, Calomys musculinus. American Journal of Tropical Medicine and Hygiene 37:663–669
     [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-69-6-1437
Loading
Is Vertical Transmission Sufficient to Maintain Junin Virus in Nature?
J. Gen. Virol. 69, 1437 (1988); https://doi.org/10.1099/0022-1317-69-6-1437
/content/journal/jgv/10.1099/0022-1317-69-6-1437
/content/journal/jgv/10.1099/0022-1317-69-6-1437
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error