@article{mbs:/content/journal/jgv/10.1099/0022-1317-69-4-931, author = "Rydbeck, Robert and Löve, Arthur and Örvell, Claes", title = "Parainfluenza Virus Type 2 Haemagglutinin-Neuraminidase Glycoprotein Characterized with Monoclonal Antibodies", journal= "Journal of General Virology", year = "1988", volume = "69", number = "4", pages = "931-935", doi = "https://doi.org/10.1099/0022-1317-69-4-931", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-4-931", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "parainfluenza virus type 2", keywords = "haemagglutinin-neuraminidase protein", keywords = "paramyxoviruses", abstract = "Summary Thirteen monoclonal antibodies (MAbs) were prepared against human parainfluenza virus type 2 (PIV2). These MAbs reacted with the haemagglutinin-neuraminidase glycoprotein with an M r of 84K. The MAbs defined one antigenic site which could be divided into five epitopes. A correlation between haemagglutination inhibition (HI) and neutralization activity could be seen although one MAb, which recognized a distinct epitope, showed neutralization and no HI activity to PIV2. The reactivity of the MAbs was tested against Sendai virus, parainfluenza virus type 3, simian virus 5 (SV5), mumps virus, Newcastle disease virus, measles virus and canine distemper virus. Only one MAb showed any cross-reaction with a low HI titre to SV5.", }