The capacity of lectins to inhibit viral haemolysis of chicken erythrocytes was tested, to evaluate the role of carbohydrate in the fusion reaction. Pretreatment of cells with pea lectin provided a 70% to 85% haemolysis inhibition with WSN influenza virus, but only 10% to 14% with PR8 influenza virus. Pea lectin did not detectably bind to virus, nor did it inhibit virus binding to cells, but it did inhibit WSN influenza virus elution. Additionally, pea lectin was active against Sendai virus and B/Lee influenza virus, but inactive against Newcastle disease virus. Haemolysis by WSN and PR8 influenza viruses was unaffected in cells pretreated with concanavalin A, peanut, wheatgerm or soybean lectins. A possible role of cellular carbohydrate in virus-cell fusion is discussed.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error