RT Journal Article SR Electronic(1) A1 Al-Saadi, S. A. A1 Gross, P. A1 Wildy, P.YR 1988 T1 Herpes Simplex Virus Type 2 Latency in the Footpad of Mice: Effect of Acycloguanosine on the Recovery of Virus JF Journal of General Virology, VO 69 IS 2 SP 433 OP 438 DO https://doi.org/10.1099/0022-1317-69-2-433 PB Microbiology Society, SN 1465-2099, AB Summary Herpes simplex virus type 2 has been reactivated from the latent state in the footpad and dorsal root ganglia of acycloguanosine-treated BALB/c mice. Virus was also recovered from the footpad tissue but not from the ganglia of denervated, latently infected mice. Treatment in vitro of explanted footpad cultures with acycloguanosine or phosphonoacetic acid did not affect the rate of virus reactivation. In all the isolates examined the virus was found to be acycloguanosine-sensitive. Recovery of virus from footpad tissue of mice after a long period of acycloguanosine treatment supports the theory that virus had been truly latent in the footpad and not in a state of persistent infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-2-433