1887

Abstract

Summary

A hantavirus, designated Leakey virus, was isolated from a captured in Real County, Texas, U.S.A. in August 1986. Virus-specific fluorescence was first detected 13 days after inoculation of Vero-E6 cells with spleen tissue from the seropositive . Ultrastructurally, the new isolate resembled other hantaviruses. Leakey virus induced a fatal meningoencephalitis in infant Fischer rats, with viral antigen detectable in brain, lung, liver, kidney and spleen. Serum dilution, plaque reduction neutralization tests indicated that Leakey virus was antigenically distinct from Hantaan, Seoul, Puumala and Prospect Hill viruses, and therefore constitutes a new serotype.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-69-12-3129
1988-12-01
2022-01-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/69/12/JV0690123129.html?itemId=/content/journal/jgv/10.1099/0022-1317-69-12-3129&mimeType=html&fmt=ahah

References

  1. CHILDS J. E., GLASS G. E., KORCH G. W., LEDUC J. W. 1987a; Prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of Baltimore, Maryland. American Journal of Tropical Medicine and Hygiene 37:648–662
    [Google Scholar]
  2. CHILDS J. E., KORCH G. W., GLASS G. E., LEDUC J. W., SHAH K. V. 1987b; Epizootiology of Hantavirus infection in Baltimore: isolation of a virus from Norway rats and characteristics of infected rat populations. American Journal of Epidemiology 126:55–68
    [Google Scholar]
  3. CHILDS J. E., GLASS G. E., KORCH G. W., ARTHUR R. R., SHAH K. V., GLASSER D., ROSSI C. 1988; Evidence of human infection with a rat-associated Hantavirus in Baltimore, Maryland. American Journal of Epidemiology 127:875–878
    [Google Scholar]
  4. LEDUC J. W., SMITH G. A., JOHNSON K. M. 1984; Hantaan-like viruses from domestic rats captured in the United States. American Journal of Tropical Medicine and Hygiene 33:992–998
    [Google Scholar]
  5. LEE H. W., LEE P.-W., JOHNSON K. M. 1978; Isolation of the etiologic agent of Korean hemorrhagic fever. Journal of Infectious Diseases 137:298–308
    [Google Scholar]
  6. LEE H. W., BAEK L. J., JOHNSON K. M. 1982; Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. Journal of Infectious Diseases 146:638–644
    [Google Scholar]
  7. LEE P.-W., AMYX H. L., YANAGIHARA R., GAJDUSEK D. C, GOLDGABER D., GIBBS C. J. JR 1985a; Partial characterization of Prospect Hill virus isolated from meadow voles in the United States. Journal of Infectious Diseases 152:826–829
    [Google Scholar]
  8. LEE P.-W., GIBBS C. J. JR, GAJDUSEK D. C., YANAGIHARA R. 1985b; Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. Journal of Clinical Microbiology 22:940–944
    [Google Scholar]
  9. MARTIN M. L., REGNERY H. L., SASSO D. R., MCCORMICK J. B., PALMER E. L. 1985; Distinction between bunyaviridae genera by surface structure and comparison with Hantaan virus using negative stain electron microscopy. Archives of Virology 86:17–28
    [Google Scholar]
  10. TKACHENKO E. A., IVANOV A. P., DONETS M. A., MIASNIKOV Y. A., RYLTSEVA E. V., GAPONOVA L. K., BASHKIRTSEV V. N., OKULOVA N. M., DROZDOV S. G., SLONOVA R. A., SOMOV G. P., ASTAKHOVA T. I. 1983; Potential reservoirs and vectors of haemorrhagic fever with renal syndrome (HFRS) in the U.S.S.R. Annales de la Société belge de médecine tropicale 63:267–269
    [Google Scholar]
  11. TSAI T. F., BAUER S. P., SASSO D. R., WHITFIELD S. G., MCCORMICK J. B., CARAWAY T. C, MCFARLAND L., BRADFORD H., KURATA T. 1985; Serological and virological evidence of Hantaan virus-related enzootic in the United States. Journal of Infectious Diseases 152:126–136
    [Google Scholar]
  12. YANAGIHARA R., GAJDUSEK D. C. 1988 Hemorrhagic fever with renal syndrome: a historical perspective and review of recent advances. CRC Handbook on Viral and Rickettsial Hemorrhagic Fevers151–188 Edited by Gear J. H. S. Boca Raton: CRC Press;
    [Google Scholar]
  13. YANAGIHARA R., GOLDGABER D., LEE P.-W., AMYX H. L., GAJDUSEK D. C, GIBBS C. J. JR, SVEDMYR A. 1984a; Propagation of nephropathia epidemica virus in cell culture. Lancet i:1013
    [Google Scholar]
  14. YANAGIHARA R., GAJDUSEK D. C, GIBBS C. J. JR, TRAUB R. 1984b; Prospect Hill virus: serological evidence for infection in mammalogists. New England Journal of Medicine 310:1325–1326
    [Google Scholar]
  15. YANAGIHARA R., CHIN C.-T., WEISS M. B., GAJDUSEK D. C., DIWAN A. R., POLAND J. B., KLEEMAN K. T., WILFERT C M., MEIKLEJOHN G., GLEZEN W. P. 1985; Serological evidence of Hantaan virus infection in the United States. American Journal of Tropical Medicine and Hygiene 34:396–399
    [Google Scholar]
  16. YANAGIHARA R., DAUM C. A., LEE P.-W., BAEK L. J., AMYX H. L., GAJDUSEK D. C., GIBBS C. J. JR 1987; Serological survey of Prospect Hill virus infection in indigenous wild rodents in the U.S.A. Transactions of the Royal Society of Tropical Medicine and Hygiene 81:42–45
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-69-12-3129
Loading
/content/journal/jgv/10.1099/0022-1317-69-12-3129
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error